May 19, 2026
Astros vs. Twins prediction: Why Minnesota is favored to win Tuesday's MLB matchup [5/19/2026]
Read Article Pirates vs. Cardinals prediction: St. Louis favored to win Tuesday's MLB matchup [5/19/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Pittsburgh Pirates vs St. Louis Cardinals predictions for MLB Tuesday.
The St. Louis Cardinals and Pittsburgh Pirates will meet in MLB action at Busch Stadium on Tuesday, starting at 7:45 PM ET.
Matthew Liberatore (2-2, 4.40 ERA) will be on the bump for the Cardinals, while the Pirates are going with Mitch Keller (4-2, 3.59 ERA).
Based on the latest simulations, Dimers' proven MLB model gives the Cardinals a slight edge with a 53% win probability over the Pirates.
This article offers an expanded analysis of Tuesday's Pirates vs. Cardinals matchup, including best bets and picks.
Pirates vs. Cardinals prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the result of Tuesday's MLB game between the Pirates and Cardinals, forming part of our MLB predictions coverage.
Our independent predictive model gives the Cardinals a 53% chance of beating the Pirates.
According to our model, the Cardinals (+1.5) have a 64% chance of covering the run line, while the over/under total of eight runs has a 54% chance of going over.
Pirates vs. Cardinals odds [5/19/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Pirates | Cardinals |
|---|---|---|
| Run Line | -1.5 (+162) | +1.5 (-190) |
| Moneyline | -101 | -116 |
| Total | o8 (-112) | u8 (-105) |
All odds are correct at the time of publication and are subject to change.
Pirates vs. Cardinals picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cardinals +1.5 | -190 |
| Moneyline | Cardinals | -116 |
| Total | Over 8 | -112 |
According to our MLB best bets, the top play to make on this game is Over 8 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Pirates vs. Cardinals game-day updates and essential details
Tuesday's MLB game between the Cardinals and Pirates at Busch Stadium is scheduled to commence at 7:45 PM ET.
- Who: Pittsburgh Pirates vs. St. Louis Cardinals
- Date: Tuesday, May 19, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict the Cardinals, with a 53% win probability, will likely beat the Pirates in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Continue reading with Dimers Pro
Join now to unlock this article and get full access to our predictions and betting tools. Cancel anytime.
$0 for 3 days
then $14.99/week
Already a Pro member? Log in
New here? See everything Pro includes
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
Advertiser disclosure
