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Pirates vs. Brewers prediction: Why Pittsburgh is favored to win Friday's MLB matchup [4/24/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Pittsburgh Pirates vs Milwaukee Brewers predictions for MLB Friday.
The Milwaukee Brewers will face the Pittsburgh Pirates, in what is expected to be a close MLB game, at American Family Field on Friday, starting at 7:40 PM ET.
The Brewers will start Brandon Woodruff (2-0, 3.42 ERA), while the Pirates have opted for Paul Skenes (3-1, 3.27 ERA).
Based on updated simulation results, Dimers' advanced MLB model gives the Pirates a slight edge with a 53% win probability over the Brewers.
This article offers an expanded analysis of Friday's Pirates vs. Brewers matchup, including best bets and picks.
Pirates vs. Brewers prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the result of Friday's MLB matchup between the Pirates and Brewers, forming part of our MLB predictions coverage.
Our leading predictive model gives the Pirates a 53% chance of beating the Brewers.
According to our model, the Brewers (+1.5) have a 61% chance of covering the run line, while the over/under total of seven runs has a 53% chance of going over.
Pirates vs. Brewers odds [4/24/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Pirates | Brewers |
|---|---|---|
| Run Line | -1.5 (+140) | +1.5 (-156) |
| Moneyline | -131 | +116 |
| Total | o7 (-110) | u7 (-110) |
All odds are correct at the time of publication and are subject to change.
Pirates vs. Brewers picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Brewers +1.5 | -156 |
| Moneyline | Brewers | +116 |
| Total | Over 7 | -110 |
According to our MLB best bets, the top play to make on this game is Over 7 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Pirates vs. Brewers game-day updates and essential details
Friday's MLB action between the Brewers and Pirates at American Family Field is scheduled to commence at 7:40 PM ET.
- Who: Pittsburgh Pirates vs. Milwaukee Brewers
- Date: Friday, April 24, 2026
- Time: 7:40 PM ET/4:40PM PT
- Venue: American Family Field
Conclusion
We predict the Pirates, with a 53% win probability, will likely beat the Brewers in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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