Pirates vs. Padres Prediction and Odds - May 28, 2022

The San Diego Padres square off with the Pittsburgh Pirates in MLB action at PETCO Park on Saturday, starting at 10:10PM ET.

The Padres will send Joe Musgrove (5-0, 1.90 ERA) to the mound, pitting him against JT Brubaker (0-4, 4.64 ERA) for the Pirates.

Dimers' top betting picks for Pirates vs. Padres, plus game predictions and best odds, are detailed in this article.

This Pittsburgh vs. San Diego betting analysis is presented by PointsBet, which has a 5x $100 Risk-Free Bets promo for new customers.

Who will win Pirates vs. Padres?

Using cutting-edge computer power and data, Dimers.com has simulated Saturday's Pirates-Padres MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently gives the Padres a 65% chance of getting the W against the Pirates.

More: Full Betting Guide for Pirates vs. Padres

Pirates vs. Padres Odds

• Run Line: Padres -1.5 (+100), Pirates +1.5 (-105)
• Moneyline: Padres -225, Pirates +210
• Total: Over/Under 7 (+102/-110)

Run Line, Moneyline and Over/Under

The Padres are -1.5 favorites against the Pirates, with +100 at BetMGM the best odds currently available.

For the underdog Pirates (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -105.

BetMGM currently has the best moneyline odds for the Padres at -225, which means you can risk $225 to win $100, for a total payout of $325, if they get the W.

On the other hand, Caesars Sportsbook currently has the best moneyline odds for the Pirates at +210, where you can bet $100 to profit $210, earning a total payout of $310, if they win.

The Over/Under for total runs scored sits at 7 with FanDuel Sportsbook, which currently has the best odds for the Over at +102, while Caesars Sportsbook currently has the best odds for the Under at -110.

As always, make sure you check the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 54% chance of covering the run line, while the Over/Under total of 7 runs is a 52% chance of going Over.

More: Predictions for Every MLB Matchup

Best Bets for Pirates vs. Padres

• Run Line: Pirates +1.5 @ -105 via Caesars Sportsbook (54% probability)
• Moneyline: Pirates @ +210 via Caesars Sportsbook (3.1% edge)
• Total: Over 7 @ +102 via FanDuel Sportsbook (52% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to help you make more informed investments with the legal sportsbooks in your state.

While the Padres are more likely to win the game, according to DimersBOT, betting on the Pirates moneyline is the best option due to the 3.1% edge identified when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen on Dimers.com is crucial to achieving long-term profitability.

Pirates vs. Padres Betting Guide

Use our interactive widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Pittsburgh vs. San Diego, and click or tap on See Matchup for more.

Dimers has full betting coverage of Saturday's Pirates-Padres matchup, including pregame predictions, best betting picks, and live scores.

Don't forget, DimersBOT updates often, so keep checking this page for the latest betting insights before Pirates vs. Padres on Saturday May 28, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Pirates vs. Padres 2022 Game Info

Saturday's matchup between the Padres and Pirates at PETCO Park is scheduled to start at 10:10PM ET.

• Who: San Diego Padres vs. Pittsburgh Pirates
• Date: Saturday May 28, 2022
• Time: 10:10PM ET / 7:10PM PT
• Venue: PETCO Park

Looking to join an online sportsbook and start betting on MLB? We've listed the best available sign-up offers in each legal betting state.

What other MLB games are on today?

Now you've got the 411 on Pirates vs. Padres, see the latest betting analysis for all upcoming MLB games in Dimers' MLB Bet Hub. There you can find probabilities and odds, plus our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.