Pirates vs. Padres Prediction and Odds - May 27, 2022

MLB action continues on Friday at 9:40PM ET as the Pittsburgh Pirates square off with the San Diego Padres at PETCO Park.

Sean Manaea (2-3, 4.04 ERA) will start for the Padres, up against José Quintana (1-2, 2.43 ERA) for the Pirates.

Dimers' best betting picks for Pirates vs. Padres, as well as game predictions and best odds, are detailed in this article.

Today's Pittsburgh vs. San Diego betting analysis is sponsored by PointsBet, which has a tasty 5x $100 Risk-Free Bets offer for new customers.

Who will win Pirates vs. Padres?

Using cutting-edge machine learning and data, Dimers.com has simulated Friday's Pirates-Padres MLB matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the Padres a 64% chance of defeating the Pirates.

More: Free Betting Analysis for Pirates vs. Padres

Pirates vs. Padres Game Odds

• Run Line: Padres -1.5 (+100), Pirates +1.5 (-115)
• Moneyline: Padres -220, Pirates +194
• Total: Over/Under 7 (-110/-105)

Run Line, Moneyline and Over/Under

The Padres are -1.5 favorites against the Pirates, with +100 at DraftKings Sportsbook the best odds currently available.

For the underdog Pirates (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -115.

DraftKings Sportsbook currently has the best moneyline odds for the Padres at -220, which means you can risk $220 to win $100, for a total payout of $320, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Pirates at +194, where you can bet $100 to profit $194, earning a total payout of $294, if they win.

The Over/Under sits at 7 with PointsBet, which currently has the best odds for the Over at -110, while BetMGM currently has the best odds for the Under at -105.

As always, make sure you check all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 57% chance of covering the run line, while the 7-run Over/Under is a 54% chance of going Over.

More: Live Scores for All Major Sports

Best Bets for Pirates vs. Padres

• Run Line: Pirates +1.5 @ -115 via BetMGM (57% probability)
• Moneyline: Pirates @ +194 via FanDuel Sportsbook (2.3% edge)
• Total: Over 7 @ -110 via PointsBet (54% probability)

Dimers' best bets are based on world-class simulations and wagering intelligence to serve you the best possible plays 24/7.

While the Padres are more likely to win the game, according to DimersBOT, taking the Pirates moneyline is the best option due to the 2.3% edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen on Dimers.com is one of the keys to achieving long-term profitability.

Pirates vs. Padres Probabilities

Use our widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Pittsburgh vs. San Diego, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Friday's Pirates-Padres matchup, including pregame predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates regularly, so check this article for the latest betting insights ahead of Pirates vs. Padres on Friday May 27, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Pirates vs. Padres 2022 Game Info

Friday's matchup between the Padres and Pirates at PETCO Park is scheduled to commence at 9:40PM ET.

• Who: San Diego Padres vs. Pittsburgh Pirates
• Date: Friday May 27, 2022
• Time: 9:40PM ET / 6:40PM PT
• Venue: PETCO Park

Looking to join an online sportsbook and start betting on MLB today? Check out the top sports betting sign-up offers in your state.

What MLB games are on today?

The Pirates and Padres aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and best bets for each and every MLB matchup in our MLB Bet Hub page.

Not only do we provide with you first-class predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out today!

Finally, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.