Pirates vs. Cubs Prediction and Odds - May 18, 2022

The Chicago Cubs and Pittsburgh Pirates meet in MLB at Wrigley Field on Wednesday, starting at 7:40PM ET.

The Cubs will send Drew Smyly (1-4, 3.64 ERA) to the mound, pitting him against Wil Crowe (2-2, 2.57 ERA) for the Pirates.

Dimers' free betting picks for Pirates vs. Cubs, as well as game predictions and best odds, are detailed below.

This Pittsburgh vs. CHI Cubs betting preview is presented by PointsBet, which has a 5x $100 Risk-Free Bets offer for new customers.

Who will win Pirates vs. Cubs?

Using cutting-edge machine learning and data, Dimers.com has simulated Wednesday's Pirates-Cubs MLB matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the Cubs a 57% chance of beating the Pirates .

More: Pirates vs. Cubs Simulated 10K Times

Pirates vs. Cubs Current Odds

• Run Line: Cubs -1.5 (+130), Pirates +1.5 (-145)
• Moneyline: Cubs -161, Pirates +145
• Total: Over/Under 8 (-105/-104)

Run Line, Moneyline and Over/Under

The Cubs are -1.5 favorites against the Pirates, with +130 at DraftKings Sportsbook the best odds currently available.

For the underdog Pirates (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -145.

Caesars Sportsbook currently has the best moneyline odds for the Cubs at -161, which means you can risk $161 to win $100, for a total payout of $261, if they get the W.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the Pirates at +145, where you can bet $100 to profit $145, earning a total payout of $245, if they win.

The Over/Under is set at 8 with DraftKings Sportsbook, which currently has the best odds for the Over at -105, while FanDuel Sportsbook currently has the best odds for the Under at -104.

As always, make sure you check all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 61% chance of covering the run line, while the 8-run Over/Under is a 51% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Pirates vs. Cubs

• Run Line: Pirates +1.5 @ -145 via BetMGM (61% probability)
• Moneyline: Pirates @ +145 via DraftKings Sportsbook (1.9% edge)
• Total: Over 8 @ -105 via DraftKings Sportsbook (51% probability)

Dimers' best bets are based on world-class simulations and wagering intelligence to bring you the best possible plays 24/7.

While the Cubs are more likely to win the game, according to DimersBOT, betting on the Pirates moneyline is the best option because of the 1.9% edge identified when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges published on Dimers.com is pivotal to achieving long-term profitability.

Pirates vs. Cubs Betting Guide

Use our dynamic widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Pittsburgh vs. CHI Cubs, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Wednesday's Pirates-Cubs matchup, including pregame predictions, top betting picks, and live win probabilities.

Remember, DimersBOT updates regularly, so check this article for any changes to our betting insights ahead of Pirates vs. Cubs on Wednesday May 18, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Pirates vs. Cubs 2022 Game Info

Wednesday's matchup between the Cubs and Pirates at Wrigley Field is scheduled to begin at 7:40PM ET.

• Date: Wednesday May 18, 2022
• Time: 7:40PM ET / 4:40PM PT
• Venue: Wrigley Field

Ready to join an online sportsbook and start betting on MLB? Check out the top sportsbook sign-up offers in your state.

What MLB games are on today?

The Pirates and Cubs aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and best bets for every single MLB matchup in our MLB Bet Hub page.

Not only do we provide with you quality predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.