Pirates vs. Cubs Prediction and Odds - Apr 22, 2022

The Chicago Cubs take on the Pittsburgh Pirates in MLB action at Wrigley Field on Friday, commencing at 8:05PM ET.

The Cubs will have Drew Smyly (1-0, 0.00 ERA) start, while the Pirates will counter with José Quintana (0-1, 3.86 ERA).

Dimers' best betting picks for Pirates vs. Cubs, as well as game predictions and best odds, are detailed in this article.

Who will win Pirates vs. Cubs?

Based on high-tech computer power and data, Dimers.com has simulated Friday's Pirates-Cubs MLB game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the Cubs a 61% chance of defeating the Pirates.

More: Pirates vs. Cubs Simulated 10,000 Times

Pirates vs. Cubs Current Odds

• Run Line: Cubs -1.5 (+126), Pirates +1.5 (-140)
• Moneyline: Cubs -165, Pirates +155
• Total: Over/Under 7.5 (-115/+100)

Run Line, Moneyline and Over/Under

The Cubs are -1.5 favorites versus the Pirates, with +126 at FanDuel Sportsbook the best odds currently available.

For the underdog Pirates (+1.5) to cover the run line, PointsBet has the best odds currently on offer at -140.

DraftKings Sportsbook currently has the best moneyline odds for the Cubs at -165, which means you can risk $165 to win $100, for a total payout of $265, if they get the W.

Elsewhere, Caesars Sportsbook currently has the best moneyline odds for the Pirates at +155, where you can bet $100 to profit $155, earning a total payout of $255, if they win.

The Over/Under for total runs scored is set at 7.5 with Caesars Sportsbook, which currently has the best odds for the Over at -115, while PointsBet currently has the best odds for the Under at +100.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 59% chance of covering the run line, while the 7.5-run Over/Under is a 54% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Pirates vs. Cubs

• Run Line: Pirates +1.5 @ -140 via PointsBet (59% probability)
• Moneyline: Pirates @ +155 via Caesars Sportsbook (0.1% edge)
• Total: Over 7.5 @ -115 via Caesars Sportsbook (54% probability)

Dimers' best bets are based on detailed simulations and betting intelligence to help you make more informed investments with the legal sportsbooks in your state.

While the Cubs are more likely to win the game, according to DimersBOT, taking the Pirates moneyline is the best option because of the edge identified when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen on Dimers.com is crucial to being profitable in the long run.

Pirates vs. Cubs Betting Guide

Use our dynamic widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for Pittsburgh vs. CHI Cubs, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Friday's Pirates-Cubs matchup, including pregame predictions, best betting picks, and live win probabilities.

Remember, DimersBOT updates frequently, so keep an eye on this article for the latest betting insights before Pirates vs. Cubs on Friday April 22, 2022.

Claim Your Risk-Free Bet for Pirates vs. Cubs

Looking for the best sportsbook promo in America for Pittsburgh vs. CHI Cubs? Join FanDuel Sportsbook now and get your first bet risk free up to $1,000, which you can use on Friday's Pirates-Cubs game.

All you need to do is click or tap on this exclusive FanDuel Sportsbook link and create an account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1,000 on Pirates vs. Cubs. If you don't win your bet, FanDuel Sportsbook will refund it in site credit!

This promo is available to all new FanDuel Sportsbook users – no promo code needed!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Pirates vs. Cubs 2022 Game Info

When do the Cubs play the Pirates?

• Date: Friday April 22, 2022
• Time: 8:05PM ET / 5:05PM PT
• Venue: Wrigley Field

Want to join an online sportsbook and start betting on MLB today? Check out the top sportsbook bonus offers in your state.

What other MLB games are on today?

The Pirates and Cubs aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and best bets for every single MLB game via our MLB Predictions page.

Not only do we provide with you quality predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out today!

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.