Pirates vs. Cubs Prediction and Odds - Apr 21, 2022

The Chicago Cubs and Pittsburgh Pirates lock horns in MLB at Wrigley Field on Thursday, starting at 7:40PM ET.

Mark Leiter Jr. (0-1, 18.90 ERA) will get the ball for the Cubs, up against Bryse Wilson (0-0, 5.40 ERA) for the Pirates.

Dimers' free betting picks for Pirates vs. Cubs, as well as game predictions and best odds, are featured in this article.

Who will win Pirates vs. Cubs?

Based on trusted computer power and data, Dimers.com has simulated Thursday's Pirates-Cubs MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Cubs a 60% chance of winning against the Pirates.

More: Pirates vs. Cubs Simulated 10,000 Times

Pirates vs. Cubs Odds

• Run Line: Cubs -1.5 (+125), Pirates +1.5 (-140)
• Moneyline: Cubs -161, Pirates +146
• Total: Over/Under 8.5 (-120/+100)

Run Line, Moneyline and Over/Under

The Cubs are currently -1.5 favorites versus the Pirates, with +125 at PointsBet the best odds currently available.

For the underdog Pirates (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on the market at -140.

Caesars Sportsbook currently has the best moneyline odds for the Cubs at -161. That means you can risk $161 to win $100, for a total payout of $261, if they get the W.

On the other hand, FanDuel Sportsbook currently has the best moneyline odds for the Pirates at +146, where you can bet $100 to profit $146, earning a total payout of $246, if they win.

The Over/Under sits at 8.5 with BetMGM, which currently has the best odds for the Over at -120, as well as the best odds for the Under at +100.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 58% chance of covering the run line, while the 8.5-run Over/Under is a 53% chance of going Over.

More: Best Bets Today for All Major Sports

Best Bets for Pirates vs. Cubs

• Run Line: Pirates +1.5 @ -140 via DraftKings Sportsbook (58% probability)
• Moneyline: Pirates @ +146 via FanDuel Sportsbook
• Total: Over 8.5 @ -120 via BetMGM (53% probability)

Dimers' best bets are based on detailed simulations and wagering intelligence to serve you the best possible plays 24/7/365.

While the Cubs are more likely to win the game, according to DimersBOT, betting on the Pirates moneyline is the best option due to the edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen on Dimers is one of the keys to being profitable in the long run.

Pirates vs. Cubs Betting Guide

Use our dynamic widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for Pittsburgh vs. CHI Cubs, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Thursday's Pirates-Cubs matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so refresh this page for any changes to our betting insights before Pirates vs. Cubs on Thursday April 21, 2022.

Best Betting Promo for Pirates vs. Cubs

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Pirates vs. Cubs 2022 Game Info

When do the Cubs play the Pirates?

• Date: Thursday April 21, 2022
• Time: 7:40PM ET / 4:40PM PT
• Venue: Wrigley Field

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Want more MLB predictions like this?

So, you liked our Pirates vs. Cubs betting analysis? Awesome. Did you know our MLB Betting News section has a comprehensive betting preview for every MLB matchup the second the sportsbooks put out their odds?

That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find edges in the markets. This allows us to create the most authoritative MLB betting previews and get the jump on the public and the sportsbooks.

It's only a click away, so why not see for yourself?

Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds on the market.