Pirates vs. Cardinals Prediction and Odds - Apr 7, 2022

The St Louis Cardinals take on the Pittsburgh Pirates on Opening Day of the 2022 MLB season at Busch Stadium on Thursday, starting at 4:15PM EDT.

Adam Wainwright (0-0, 0.00 ERA) will start on the mound for the Cardinals, while the Pirates will counter with JT Brubaker (0-0, 0.00 ERA).

Dimers' best betting picks for Pirates vs. Cardinals, as well as game predictions and best odds, are featured in this article.

Who will win Pirates vs. Cardinals?

Using high-tech machine learning and data, Dimers.com has simulated Thursday's Pirates-Cardinals MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Cardinals a 63% chance of beating the Pirates.

MORE: Free Betting Guide for Pirates vs. Cardinals

Run Line, Moneyline and Over/Under

The Cardinals are currently -1.5 favorites versus the Pirates, with +128 at FanDuel Sportsbook the best odds currently available.

For the underdog Pirates (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at -115.

BetMGM currently has the best moneyline odds for the Cardinals at -160. That means you can risk $160 to win $100, for a total payout of $260, if they get the W.

On the other hand, DraftKings Sportsbook currently has the best moneyline odds for the Pirates at +170, where you can bet $100 to profit $170, earning a total payout of $270, if they win.

The Over/Under is set at 8 with FanDuel Sportsbook, which currently has the best odds for the Over at -102, while DraftKings Sportsbook currently has the best odds for the Under at -105.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Pirates (+1.5) are a 55% chance of covering the run line, while the Over/Under total of 8 runs is a 51% chance of going Over.

MORE: Live Scores for All Major Sports

Best Bets for Pirates vs. Cardinals

• Run Line: Cardinals -1.5 @ +128 via FanDuel Sportsbook (1.4% edge)
• Moneyline: Cardinals @ -160 via BetMGM (63% probability)
• Over/Under: Over 8 @ -102 via FanDuel Sportsbook (51% probability)

Dimers' best bets are based on complex simulations and betting intelligence to bring you the best possible plays every time.

Although the Pirates are more likely to cover the run line, our best bet of Cardinals -1.5 is based on the expectation of that happening, according to DimersBOT, and the best odds available.

Pirates vs. Cardinals Probabilities

Use our interactive widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for Pittsburgh vs. St Louis, and click or tap on See Matchup for more.

Dimers has full coverage of Thursday's Pirates-Cardinals matchup, including pre-game predictions, best betting picks, and live scores.

Don't forget, DimersBOT updates regularly, so check this page for any changes to our betting insights ahead of Pirates vs. Cardinals on Thursday April 7, 2022.

Get a Risk-Free Bet for Pirates vs. Cardinals

Do you want to bet on Pittsburgh vs. St Louis? Join FanDuel Sportsbook today and get a risk-free first bet up to $1,000, which you can use on Thursday's Pirates-Cardinals game.

Simply click or tap on this exclusive FanDuel Sportsbook link and create an account – it's easy and takes less than 2 minutes.

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This promo is available to all new FanDuel Sportsbook users. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Pirates vs. Cardinals 2022 Game Info

When do the Cardinals play the Pirates?

• Date: Thursday April 7, 2022
• Time: 4:15PM EDT / 1:15PM PDT
• Venue: Busch Stadium

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