Pepperdine vs. Santa Clara prediction: Santa Clara favored to win men's college basketball matchup [1/2/2026]

Men's college basketball action continues on Friday at 10:00 PM ET as Pepperdine takes on Santa Clara in men's college basketball action at Leavey Center.

Based on the latest simulations, Dimers' proven college basketball model projects Santa Clara as the most likely winner of the Pepperdine vs. Santa Clara game.

This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Pepperdine vs. Santa Clara prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the result of Friday's NCAA basketball game between Pepperdine and Santa Clara 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Santa Clara a 96% chance of defeating Pepperdine. Our predicted final score has Santa Clara winning 85-64.

According to our model, Santa Clara (-19.5) has a 53% chance of covering the spread, while the 150.5-point over/under has a 52% chance of staying under.

Pepperdine vs. Santa Clara odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Pepperdine vs. Santa Clara picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: