Pepperdine vs. Santa Clara prediction: Santa Clara favored to win men's college basketball matchup [1/2/2026]

Santa Clara and Pepperdine are scheduled to meet in men's college basketball action at Leavey Center on Friday, with tipoff at 10:00 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model projects Santa Clara as the most likely winner of the Pepperdine vs. Santa Clara game.

This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Pepperdine vs. Santa Clara prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Friday's NCAA basketball game between Pepperdine and Santa Clara 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Santa Clara a 96% chance of beating Pepperdine. Our predicted final score has Santa Clara winning 85-64.

According to our model, Santa Clara (-20.5) has a 52% chance of covering the spread, while the 150.5-point over/under has a 54% chance of staying under.

Pepperdine vs. Santa Clara odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Pepperdine vs. Santa Clara picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best men's college basketball bets, the top play to make on this game is Under 150.5 total points.

Pepperdine vs. Santa Clara game-day updates and essential details

Friday's men's college basketball matchup between Santa Clara and Pepperdine at Leavey Center is scheduled to begin at 10:00 PM ET.

• Who: Pepperdine vs. Santa Clara
• Date: Friday, January 2, 2026
• Time: 10:00 PM ET/7:00PM PT
• Venue: Leavey Center

Conclusion

We predict Santa Clara, with a 96% win probability, will likely beat Pepperdine on Friday.

AI and automation have enhanced this article to quickly deliver accurate Pepperdine vs. Santa Clara insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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