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Penn State vs. Indiana prediction: Why Indiana is favored to win men's college basketball matchup [12/9/2025]

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Written by Dave Garofolo

Get Penn State vs Indiana predictions for college basketball Tuesday.

Penn State-Indiana Predictions and Game Preview.
Penn State vs. Indiana men's college basketball prediction for Tuesday, December 9, 2025.

Indiana will square off with Penn State in men's college basketball action at Simon Skjodt Assembly Hall on Tuesday, commencing at 8:30PM ET.

Based on updated simulations, Dimers' proven college basketball model predicts Indiana as the most likely winner of the Penn State vs. Indiana game.

This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Penn State vs. Indiana prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the outcome of Tuesday's NCAA basketball matchup between Penn State and Indiana 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Indiana a 92% chance of beating Penn State. Our predicted final score has Indiana winning 84-68.

According to our model, Indiana (-15.5) has a 53% chance of covering the spread, while the 154.5-point over/under has a 52% chance of staying under.

 

Penn State vs. Indiana odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

Bet Type Penn State Indiana
Spread +15.5 (-106) -15.5 (-110)
Moneyline +900 -1600
Total o154.5 (-110) u154.5 (-105)

All odds are correct at the time of publication and are subject to change.

Penn State vs. Indiana picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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