Penguins vs. Sabres Predictions and Odds - Mar 23, 2022

The Buffalo Sabres take on the favored Pittsburgh Penguins in NHL action at KeyBank Center on Wednesday, commencing at 7:30PM EDT.

Dimers' top betting picks for Penguins vs. Sabres, plus game predictions, best odds and player props, are featured in this article.

Who will win Penguins vs. Sabres?

Using state-of-the-art computer power and data, Dimers.com has simulated Wednesday's Penguins-Sabres NHL matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, gives the Penguins a 65% chance of beating the Sabres.

MORE: Free Betting Analysis for Penguins vs. Sabres

Puck Line, Moneyline and Over/Under

The Sabres are listed as +1.5 underdogs versus the Penguins, with -135 at BetMGM the best odds currently available.

For the favored Penguins (-1.5) to cover the puck line, DraftKings Sportsbook has the best odds currently on the market at +120.

PointsBet currently has the best moneyline odds for the Sabres at +190, which means you can bet $100 to profit $190, earning a total payout of $290, if they win.

On the other hand, BetMGM currently has the best moneyline odds for the Penguins at -225, where you can risk $225 to win $100, for a total payout of $325, if they come out on top.

The Over/Under for total goals scored is set at 6 with Caesars Sportsbook, which currently has the best odds for the Over at -130, while PointsBet currently has the best odds for the Under at +110.

As always, check out the sportsbooks you can bet with in your state for the best NHL odds and lines.

According to DimersBOT, the Sabres (+1.5) are a 58% chance of covering the puck line, while the 6-goal Over/Under is a 51% chance of going Over.

MORE: Best Bets Today for All Major Sports

Best Bets for Penguins vs. Sabres

• Puck Line: Sabres +1.5 at -135 with BetMGM (58% probability)
• Moneyline: Sabres at +190 with PointsBet (0.9% edge)
• Over/Under: Under 6 at +110 with PointsBet (1.8% edge)

Dimers' best bets are based on world-class simulations and wagering intelligence to serve you the best possible plays 24/7/365.

While the Penguins are more likely to win the game, according to DimersBOT, taking the Sabres moneyline is the best option because of the edge found when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges published here at Dimers is one of the keys to being a profitable sports bettor in the long run.

Furthermore, despite the Over being more likely to hit on this occasion, Under 6 is our best bet on account of the better odds (+110) that are available from PointsBet.

Penguins vs. Sabres Betting Guide

Use our widget below to see up-to-date Moneyline, Over/Under and Puck Line probabilities and odds for Pittsburgh vs. Buffalo, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Wednesday's Penguins-Sabres matchup, including pre-game predictions, best betting picks, and live win probabilities.

Penguins vs. Sabres Player Props

Who will score the first goal in Penguins vs. Sabres? The latest data is in.

Listed below are the most likely first goal and most likely anytime goal scorers for both the Penguins and Sabres.

And you know what, we provide this information to you for FREE to help you discover the best prop picks for Wednesday's game.

According to DimersBOT, Pittsburgh's Jake Guentzel is most likely to score the first goal in Penguins vs. Sabres.

DimersBOT gives Guentzel a 7.0% chance of scoring the first goal at KeyBank Center, while the Penguins star is a 35.4% chance of netting an anytime goal.

Scroll down for the full list of first and anytime goal scorer probabilities.

First Goal Scorer Prediction

Pittsburgh Penguins

• Jake Guentzel: 7.0% probability
• Bryan Rust: 6.5% probability
• Sidney Crosby: 6.4% probability
• Evgeni Malkin: 6.1% probability
• Rickard Rakell: 4.6% probability

Buffalo Sabres

• Tage Thompson: 6.8% probability
• Jeff Skinner: 4.3% probability
• Victor Olofsson: 4.1% probability
• Alex Tuch: 3.9% probability
• Kyle Okposo: 3.7% probability

Anytime Goal Scorer Prediction

Pittsburgh Penguins

• Jake Guentzel: 35.4% probability
• Sidney Crosby: 34.9% probability
• Bryan Rust: 32.8% probability
• Evgeni Malkin: 31.2% probability
• Rickard Rakell: 24.2% probability

Buffalo Sabres

• Tage Thompson: 31.7% probability
• Jeff Skinner: 23.5% probability
• Alex Tuch: 22.8% probability
• Victor Olofsson: 22.5% probability
• Kyle Okposo: 20.5% probability

Don't forget, DimersBOT updates regularly, so refresh this article for any changes to our betting analysis before Penguins vs. Sabres on Wednesday March 23, 2022.

Penguins vs. Sabres $10 Live Free Bet Promo

Free bet alert! New and existing BetMGM users can get a $10 Free Bet to use on any sport when they place a $50+ live bet on Pittsburgh vs. Buffalo this Wednesday.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Penguins vs. Sabres 2022 Game Info

When do the Sabres play the Penguins?

• Date: Wednesday March 23, 2022
• Time: 7:30PM EDT / 4:30PM PDT
• Venue: KeyBank Center

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What NHL games are on tonight?

The Penguins and Sabres aren't the only two NHL teams you can bet on tonight. DimersBOT never stops and we've got picks and top bets for every single NHL matchup in our NHL Bet Hub page.

Not only do we provide with you great predictions, but we also have recommended bets for the Puck Line, Over/Under and Moneyline. Sound good? Check it out now!