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Patriots vs. Bills Week 18 Prediction and Odds - Jan 8, 2023

The Buffalo Bills face the New England Patriots in NFL Week 18 action at Highmark Stadium on Sunday, commencing at 1:00PM ET.
Dimers' best betting picks for Patriots vs. Bills, plus our score prediction, betting odds and touchdown scorer probabilities, are detailed in this article.
Who will win Patriots vs. Bills?
Based on cutting-edge machine learning and data, Dimers.com has simulated Sunday's Patriots-Bills NFL game 10,000 times.
Dimers' leading predictive analytics model, DimersBOT, gives the Bills a 78% chance of beating the Patriots in Week 18 of the NFL season.
More: Patriots vs. Bills Simulated 10,000 Times
Patriots vs. Bills Odds
- Spread: Bills -7 (-110), Patriots +7 (-110)
- Moneyline: Bills -350, Patriots +320
- Total: Over/Under 43.5 (-115/-110)
Point Spread, Moneyline and Over/Under
The Bills are listed as -7 favorites against the Patriots, with -110 at Caesars Sportsbook the best odds currently available.
For the underdog Patriots (+7) to cover the spread, Caesars Sportsbook also has the best odds currently on offer at -110.
PointsBet currently has the best moneyline odds for the Bills at -350. That means you can risk $350 to win $100, for a total payout of $450, if they get the W.
Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Patriots at +320, where you can bet $100 to profit $320, earning a total payout of $420, if they win.
The Over/Under for total points scored is set at 43.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -115, while Caesars Sportsbook currently has the best odds for the Under at -110.
As always, check out all the sportsbooks that are available in your state for the best NFL odds and lines.
According to DimersBOT, the Bills (-7) are a 52% chance of covering the spread, while the Over/Under total of 43.5 points is a 52% chance of going Over.
More: Best Free Bet Tracker
Best Bets for Patriots vs. Bills
- Spread: Bills -7 @ -110 via Caesars Sportsbook (52% probability)
- Moneyline: Bills @ -350 via PointsBet (78% probability)
- Total: Over 43.5 @ -115 via FanDuel Sportsbook (52% probability)
Dimers' best bets are based on detailed simulations and gambling expertise to help you make more informed decisions with the legal sportsbooks in the USA.
Patriots vs. Bills Prediction
Dimers.com's predicted final score for New England vs. Buffalo at Highmark Stadium in Week 18 has the Bills winning 26-18.
Click or tap on See Matchup for more.
Dimers has full coverage of this week's Patriots-Bills matchup in Week 18, including pregame predictions, computer picks, and live win probabilities.
Patriots vs. Bills Player Props
Who will score the first touchdown in Patriots vs. Bills? The latest data is in.
Listed below are the most likely first touchdown and most likely anytime touchdown scorers for both the Patriots and Bills, as well as player stat projections.
And you know what, we provide this information to you for FREE to help you choose the best prop picks for Sunday's game.
According to DimersBOT, Buffalo's Stefon Diggs is most likely to score the first touchdown in Patriots vs. Bills.
DimersBOT gives Diggs an 11.2% chance of getting in for six first at Highmark Stadium, while the Bills WR is a 45.4% chance of scoring an anytime touchdown.
Scroll down for the complete list of first and anytime TD scorer probabilities.
First Touchdown Scorer Probabilities
New England Patriots
- Rhamondre Stevenson: 7.4% probability
- Damien Harris: 7.0% probability
- Hunter Henry: 5.7% probability
- Jakobi Meyers: 5.6% probability
- Kendrick Bourne: 4.6% probability
Buffalo Bills
- Stefon Diggs: 11.2% probability
- Josh Allen: 8.8% probability
- Gabe Davis: 8.0% probability
- Devin Singletary: 7.0% probability
- James Cook: 6.5% probability
Anytime Touchdown Scorer Probabilities
New England Patriots
- Rhamondre Stevenson: 32.4% probability
- Damien Harris: 30.2% probability
- Hunter Henry: 26.3% probability
- Jakobi Meyers: 25.6% probability
- Kendrick Bourne: 21.2% probability
Buffalo Bills
- Stefon Diggs: 45.4% probability
- Josh Allen: 36.8% probability
- Gabe Davis: 33.5% probability
- Devin Singletary: 29.7% probability
- James Cook: 28.3% probability
Patriots-Bills Projected Player Stats
Of the starting quarterbacks, the Patriots' Mac Jones is projected for 201 passing yards. The Bills' Josh Allen is expected to throw for 256 yards.
Patriots Starting QB
- Mac Jones: 201 projected yards
Bills Starting QB
- Josh Allen: 256 projected yards
Patriots Rushing
- Rhamondre Stevenson: 54 projected yards
- Damien Harris: 48 projected yards
- Mac Jones: 11 projected yards
Bills Rushing
- Devin Singletary: 51 projected yards
- Josh Allen: 43 projected yards
- James Cook: 33 projected yards
Patriots Receiving
- Jakobi Meyers: 47 projected yards
- Kendrick Bourne: 43 projected yards
- DeVante Parker: 40 projected yards
- Hunter Henry: 36 projected yards
- Tyquan Thornton: 30 projected yards
Bills Receiving
- Stefon Diggs: 74 projected yards
- Gabe Davis: 51 projected yards
- Isaiah McKenzie: 31 projected yards
- Dawson Knox: 28 projected yards
- James Cook: 19 projected yards
Remember, DimersBOT updates regularly, so refresh this page for any changes to our betting insights before Patriots vs. Bills on Sunday January 8, 2023.
Patriots vs. Bills 2023
The NFL Week 18 action between the Bills and Patriots at Highmark Stadium is scheduled to begin at 1:00PM ET.
- Who: New England Patriots vs. Buffalo Bills
- Date: Sunday January 8, 2023
- Time: 1:00PM ET / 10:00AM PT
- Venue: Highmark Stadium
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