Padres vs. Reds Prediction and Odds - Apr 28, 2022

The Cincinnati Reds and San Diego Padres clash in MLB at Great American Ball Park on Thursday, starting at 12:35PM ET.

Tyler Mahle (1-2, 6.88 ERA) will be on the bump for the Reds, while the Padres are going with Nick Martinez (0-2, 4.30 ERA).

Dimers' free betting picks for Padres vs. Reds, plus game predictions and best odds, are featured below.

Who will win Padres vs. Reds?

Using state-of-the-art machine learning and data, Dimers.com has simulated Thursday's Padres-Reds MLB game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Padres a 51% chance of defeating the Reds.

More: Padres vs. Reds Simulated 10K Times

Padres vs. Reds Game Odds

• Run Line: Reds +1.5 (-170), Padres -1.5 (+158)
• Moneyline: Reds -104, Padres -105
• Total: Over/Under 7.5 (-115/-105)

Run Line, Moneyline and Over/Under

The Reds are +1.5 underdogs against the Padres, with -170 at DraftKings Sportsbook the best odds currently available.

For the favored Padres (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +158.

In a sign of how close this game is expected to be, both the Reds and Padres are currently at minus-money betting odds on the moneyline.

FanDuel Sportsbook currently has the best moneyline odds for the Reds at -104, which means you can risk $104 to win $100, for a total payout of $204, if they get the W.

On the other hand, PointsBet currently has the best moneyline odds for the Padres at -105, where you can risk $105 to win $100, for a total payout of $205, if they come out on top.

The Over/Under for total runs scored is set at 7.5 with Caesars Sportsbook, which currently has the best odds for the Over at -115, while PointsBet currently has the best odds for the Under at -105.

As always, check out all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Reds (+1.5) are a 63% chance of covering the run line, while the 7.5-run Over/Under is a 55% chance of going Over.

More: Best Bets Today for All Major Sports

Best Bets for Padres vs. Reds

• Run Line: Reds +1.5 @ -170 via DraftKings Sportsbook (63% probability)
• Moneyline: Padres @ -105 via PointsBet (51% probability)
• Total: Over 7.5 @ -115 via Caesars Sportsbook (55% probability)

Dimers' best bets are based on detailed simulations and betting intelligence to help you make smarter decisions with the legal sportsbooks in your state.

Padres vs. Reds Betting Guide

Use our interactive widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for San Diego vs. Cincinnati, and click or tap on See Matchup for more.

Dimers has full betting coverage of this Padres-Reds matchup, including pregame predictions, free betting picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so check this article for the latest betting insights before Padres vs. Reds on Thursday April 28, 2022.

Best Betting Promo for Padres vs. Reds

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Padres vs. Reds 2022 Game Info

When do the Reds play the Padres?

• Date: Thursday April 28, 2022
• Time: 12:35PM ET / 9:35AM PT
• Venue: Great American Ball Park

Looking to join an online sportsbook and start betting on MLB today? We've got access to the best available welcome offers in every legal betting state.

What other MLB games are on today?

Now you've got the 411 on Padres vs. Reds, get the latest betting analysis for all upcoming MLB games in our MLB Bet Hub. There you can find probabilities and odds, as well as our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Finally, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.