Padres vs. Guardians Prediction and Odds - May 4, 2022

The Cleveland Guardians square off with the San Diego Padres in MLB action at Progressive Field on Wednesday, beginning at 1:10PM ET.

The Guardians will send Cal Quantrill (1-1, 3.27 ERA) to the mound, while the Padres are going with MacKenzie Gore (2-0, 1.76 ERA).

Dimers' top betting picks for Padres vs. Guardians, plus game predictions and best odds, are featured in this article.

This San Diego vs. Cleveland betting analysis is proudly sponsored by PointsBet, which has a tasty 5x $100 Risk-Free Bets offer for new customers.

Who will win Padres vs. Guardians?

Based on cutting-edge computer power and data, Dimers.com has simulated Wednesday's Padres-Guardians MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Padres a 56% chance of defeating the Guardians.

More: Padres vs. Guardians Simulated 10K Times

Padres vs. Guardians Odds

• Run Line: Guardians +1.5 (-140), Padres -1.5 (+136)
• Moneyline: Guardians +125, Padres -138
• Total: Over/Under 7 (-115/+100)

Run Line, Moneyline and Over/Under

The Guardians are listed as +1.5 underdogs versus the Padres, with -140 at BetMGM the best odds currently available.

For the favored Padres (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +136.

BetMGM currently has the best moneyline odds for the Guardians at +125. That means you can throw down $100 to profit $125, earning a total payout of $225, if they win.

On the other hand, FanDuel Sportsbook currently has the best moneyline odds for the Padres at -138, where you can risk $138 to win $100, for a total payout of $238, if they come out on top.

The Over/Under sits at 7 with BetMGM, which currently has the best odds for the Over at -115, while DraftKings Sportsbook currently has the best odds for the Under at +100.

As always, make sure you check the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 57% chance of covering the run line, while the 7-run Over/Under is a 67% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Padres vs. Guardians

• Run Line: Padres -1.5 @ +136 via FanDuel Sportsbook (0.3% edge)
• Moneyline: Guardians @ +125 via BetMGM
• Total: Over 7 @ -115 via BetMGM (67% probability) 🔥

Every time you see a 🔥, you know you've found one of our best bets of the day across all sports.

Dimers' best bets are based on world-class simulations and betting intelligence to help you make smarter investments with the legal sportsbooks in America.

Even though the Guardians are more likely to cover the run line, our best bet of Padres -1.5 is based on the expectation of that happening, according to DimersBOT, and the top odds available.

And while the Padres are more likely to win the game, according to DimersBOT, betting on the Guardians moneyline is the best option due to the edge identified when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges seen here at Dimers is pivotal to being profitable in the long run.

Padres vs. Guardians Probabilities

Use our interactive widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for San Diego vs. Cleveland, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Wednesday's Padres-Guardians matchup, including pregame predictions, free betting picks, and live updates.

Don't forget, DimersBOT updates frequently, so keep checking this page for any changes to our betting insights ahead of Padres vs. Guardians on Wednesday May 4, 2022.

Risk-Free Bet for Padres vs. Guardians

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Padres vs. Guardians 2022 Game Info

When do the Guardians play the Padres?

• Date: Wednesday May 4, 2022
• Time: 1:10PM ET / 10:10AM PT
• Venue: Progressive Field

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Want more MLB analysis like this?

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That's right, our predictive analytics model then compares those odds against its own probabilities to find edges in the markets. This allows us to write the most accurate MLB betting previews and beat the public and the sportsbooks to the punch.

It's only a click away, so why not see for yourself?

Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds on the market.