Padres vs. Guardians Prediction and Odds - May 3, 2022

The Cleveland Guardians and San Diego Padres are scheduled to meet in MLB at Progressive Field on Tuesday, starting at 6:10PM ET.

Zach Plesac (1-2, 3.80 ERA) will start for the Guardians, while the Padres are going with Mike Clevinger (0-0, 0.00 ERA).

Dimers' best betting picks for Padres vs. Guardians, plus game predictions and best odds, are featured in this article.

Today's San Diego vs. Cleveland betting preview is brought to you by PointsBet, which has a 5x $100 Risk-Free Bets promo for new users.

Who will win Padres vs. Guardians?

Based on trusted computer power and data, Dimers.com has simulated Tuesday's Padres-Guardians MLB game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the Padres a 55% chance of defeating the Guardians.

More: Free Betting Guide for Padres vs. Guardians

Padres vs. Guardians Odds

• Run Line: Guardians +1.5 (-140), Padres -1.5 (+130)
• Moneyline: Guardians +120, Padres -134
• Total: Over/Under 8 (-120/+105)

Run Line, Moneyline and Over/Under

The Guardians are +1.5 underdogs versus the Padres, with -140 at BetMGM the best odds currently available.

For the favored Padres (-1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at +130.

BetMGM currently has the best moneyline odds for the Guardians at +120, which means you can bet $100 to profit $120, earning a total payout of $220, if they win.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Padres at -134, where you can risk $134 to win $100, for a total payout of $234, if they come out on top.

The Over/Under sits at 8 with BetMGM, which currently has the best odds for the Over at -120, while PointsBet currently has the best odds for the Under at +105.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 58% chance of covering the run line, while the Over/Under total of 8 runs is a 57% chance of going Over.

More: Best Bets for Every MLB Matchup

Best Bets for Padres vs. Guardians

• Run Line: Guardians +1.5 @ -140 via BetMGM (58% probability)
• Moneyline: Guardians @ +120 via BetMGM
• Total: Over 8 @ -120 via BetMGM (57% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to serve you the best possible plays 24/7/365.

While the Padres are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option due to the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published on Dimers.com is crucial to achieving long-term profitability as a bettor.

Padres vs. Guardians Betting Guide

Use our interactive widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for San Diego vs. Cleveland, and click or tap on See Matchup for more.

Dimers has full betting coverage of Tuesday's Padres-Guardians matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep checking this article for the latest betting analysis ahead of Padres vs. Guardians on Tuesday May 3, 2022.

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Padres vs. Guardians 2022 Game Info

When do the Guardians play the Padres?

• Date: Tuesday May 3, 2022
• Time: 6:10PM ET / 3:10PM PT
• Venue: Progressive Field

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