Orioles vs. Yankees Prediction and Odds - May 25, 2022

The New York Yankees and Baltimore Orioles lock horns in MLB at Yankee Stadium on Wednesday, starting at 7:05PM ET.

The Yankees will have JP Sears (1-0, 0.00 ERA) start, pitting him against Tyler Wells (1-3, 4.41 ERA) for the Orioles.

Dimers' top betting picks for Orioles vs. Yankees, as well as game predictions and best odds, are featured below.

This Baltimore vs. NY Yankees betting analysis is proudly sponsored by PointsBet, which has a great 5x $100 Risk-Free Bets promo for new users.

Who will win Orioles vs. Yankees?

Using trusted computer power and data, Dimers.com has simulated Wednesday's Orioles-Yankees MLB game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, gives the Yankees a 60% chance of defeating the Orioles.

More: Orioles vs. Yankees Simulated 10,000 Times

Orioles vs. Yankees Odds

• Run Line: Yankees -1.5 (+136), Orioles +1.5 (-145)
• Moneyline: Yankees -155, Orioles +140
• Total: Over/Under 7.5 (-110/-105)

Run Line, Moneyline and Over/Under

The Yankees are -1.5 favorites against the Orioles, with +136 at FanDuel Sportsbook the best odds currently available.

For the underdog Orioles (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at -145.

BetMGM currently has the best moneyline odds for the Yankees at -155. That means you can risk $155 to win $100, for a total payout of $255, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Orioles at +140, where you can bet $100 to profit $140, earning a total payout of $240, if they win.

The Over/Under for total runs scored sits at 7.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while BetMGM currently has the best odds for the Under at -105.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Orioles (+1.5) are a 59% chance of covering the run line, while the 7.5-run Over/Under is a 52% chance of going Over.

More: Free Online Bet Tracker

Best Bets for Orioles vs. Yankees

• Run Line: Orioles +1.5 @ -145 via DraftKings Sportsbook (59% probability)
• Moneyline: Yankees @ -155 via BetMGM (60% probability)
• Total: Over 7.5 @ -110 via Caesars Sportsbook (52% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to help you make smarter decisions with the legal sportsbooks in the USA.

Orioles vs. Yankees Probabilities

Use our interactive widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Baltimore vs. NY Yankees, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Wednesday's Orioles-Yankees matchup, including pregame predictions, free picks, and live scores.

Remember, DimersBOT updates often, so keep an eye on this page for any changes to our betting analysis before Orioles vs. Yankees on Wednesday May 25, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Orioles vs. Yankees 2022 Game Info

Wednesday's game between the Yankees and Orioles at Yankee Stadium is scheduled to commence at 7:05PM ET.

• Who: New York Yankees vs. Baltimore Orioles
• Date: Wednesday May 25, 2022
• Time: 7:05PM ET / 4:05PM PT
• Venue: Yankee Stadium

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What other MLB games are on today?

The Orioles and Yankees aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and best bets for every single MLB game in our MLB Bet Hub section.

Not only do we provide with you great predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

While you're here, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.