Orioles vs. Red Sox Prediction and Odds - May 27, 2022

The Boston Red Sox and Baltimore Orioles lock horns in MLB at Fenway Park on Friday, starting at 7:10PM ET.

The Red Sox will have Garrett Whitlock (1-1, 3.58 ERA) start, while the Orioles will counter with Kyle Bradish (1-3, 5.74 ERA).

Dimers' best betting picks for Orioles vs. Red Sox, plus game predictions and best odds, are detailed below.

This Baltimore vs. Boston betting analysis is sponsored by PointsBet, which has a 5x $100 Risk-Free Bets offer for new users.

Who will win Orioles vs. Red Sox?

Using state-of-the-art machine learning and data, Dimers.com has simulated Friday's Orioles-Red Sox MLB game 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, currently gives the Red Sox a 63% chance of defeating the Orioles.

More: Orioles vs. Red Sox Simulated 10,000 Times

Orioles vs. Red Sox Odds

• Run Line: Red Sox -1.5 (+105), Orioles +1.5 (-118)
• Moneyline: Red Sox -175, Orioles +155
• Total: Over/Under 10 (-105/-110)

Run Line, Moneyline and Over/Under

The Red Sox are -1.5 favorites versus the Orioles, with +105 at DraftKings Sportsbook the best odds currently available.

For the underdog Orioles (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -118.

Caesars Sportsbook currently has the best moneyline odds for the Red Sox at -175, which means you can risk $175 to win $100, for a total payout of $275, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Orioles at +155, where you can bet $100 to profit $155, earning a total payout of $255, if they win.

The Over/Under is set at 10 with BetMGM, which currently has the best odds for the Over at -105, while PointsBet currently has the best odds for the Under at -110.

As always, make sure you check all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Orioles (+1.5) are a 55% chance of covering the run line, while the 10-run Over/Under is a 54% chance of going Under.

More: Live Scores for All Major Sports

Best Bets for Orioles vs. Red Sox

• Run Line: Orioles +1.5 @ -118 via FanDuel Sportsbook (55% probability)
• Moneyline: Red Sox @ -175 via Caesars Sportsbook (63% probability)
• Total: Under 10 @ -110 via PointsBet (54% probability)

Dimers' best bets are based on detailed simulations and wagering intelligence to help you make more informed decisions with the legal sportsbooks in the United States.

Orioles vs. Red Sox Betting Guide

Use our dynamic widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for Baltimore vs. Boston, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Friday's Orioles-Red Sox matchup, including pregame predictions, top betting picks, and live win probabilities.

Remember, DimersBOT updates often, so check this article for any changes to our betting insights ahead of Orioles vs. Red Sox on Friday May 27, 2022.

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Orioles vs. Red Sox 2022 Game Info

Friday's action between the Red Sox and Orioles at Fenway Park is scheduled to start at 7:10PM ET.

• Who: Boston Red Sox vs. Baltimore Orioles
• Date: Friday May 27, 2022
• Time: 7:10PM ET / 4:10PM PT
• Venue: Fenway Park

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We use the power of predictive analytics to find value in the markets so we can publish the best MLB betting previews available. We do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

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While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.