Orioles vs. Guardians Prediction and Odds - Sep 1, 2022

The Cleveland Guardians and Baltimore Orioles meet in MLB at Progressive Field on Thursday, starting at 6:10PM ET.

The Guardians will send Shane Bieber (8-7, 3.02 ERA) to the mound, while the Orioles will counter with Kyle Bradish (2-5, 5.62 ERA).

Dimers' best betting picks for Orioles vs. Guardians, as well as game predictions and best odds, are featured in this article.

Who will win Orioles vs. Guardians?

Using cutting-edge machine learning and data, Dimers.com has simulated Thursday's Orioles-Guardians MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Guardians a 62% chance of beating the Orioles.

More: Orioles vs. Guardians Simulated 10,000 Times

Orioles vs. Guardians Game Odds

• Run Line: Guardians -1.5 (+115), Orioles +1.5 (-135)
• Moneyline: Guardians -184, Orioles +160
• Total: Over/Under 7.5 (+100/-112)

Run Line, Moneyline and Over/Under

The Guardians are -1.5 favorites versus the Orioles, with +115 at DraftKings Sportsbook the best odds currently available.

For the underdog Orioles (+1.5) to cover the run line, PointsBet has the best odds currently on offer at -135.

FanDuel Sportsbook currently has the best moneyline odds for the Guardians at -184. That means you can risk $184 to win $100, for a total payout of $284, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Orioles at +160, where you can bet $100 to profit $160, earning a total payout of $260, if they win.

The Over/Under is set at 7.5 with BetMGM, which currently has the best odds for the Over at +100, while FanDuel Sportsbook currently has the best odds for the Under at -112.

As always, make sure you check all of the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Orioles (+1.5) are a 57% chance of covering the run line, while the 7.5-run Over/Under is a 52% chance of going Over.

More: Track Your Bets via Dimers' Bet Center

Best Bets for Orioles vs. Guardians

• Run Line: Orioles +1.5 @ -135 via PointsBet (57% probability)
• Moneyline: Orioles @ +160 via DraftKings Sportsbook
• Total: Over 7.5 @ +100 via BetMGM (52% probability)

Dimers' best bets are based on complex modeling and betting expertise to serve you the best possible plays every day of the year.

While the Guardians are more likely to win the game, according to DimersBOT, betting on the Orioles moneyline is the best option due to the edge identified when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges seen on Dimers.com is pivotal to being profitable in the long run.

Orioles vs. Guardians Prediction

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Dimers has full betting coverage of Thursday's Orioles-Guardians matchup, including pregame predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates regularly, so check this article for any changes to our betting analysis before Orioles vs. Guardians on Thursday September 1, 2022.

Orioles vs. Guardians 2022 Game Info

Thursday's game between the Guardians and Orioles at Progressive Field is scheduled to start at 6:10PM ET.

• Who: Baltimore Orioles vs. Cleveland Guardians
• Date: Thursday September 1, 2022
• Time: 6:10PM ET / 3:10PM PT
• Venue: Progressive Field

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What other MLB games are on today?

The Orioles and Guardians aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and best bets for every single MLB matchup via our MLB Predictions section.

Not only do we provide with you quality predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out now!

Finally, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.