Orioles vs. Cardinals Prediction and Odds - May 11, 2022

The St Louis Cardinals and Baltimore Orioles are scheduled to meet in MLB at Busch Stadium on Wednesday, starting at 7:45PM ET.

Miles Mikolas (2-1, 1.53 ERA) will be on the bump for the Cardinals, pitting him against Spenser Watkins (0-0, 3.22 ERA) for the Orioles.

Dimers' top betting picks for Orioles vs. Cardinals, as well as game predictions and best odds, are featured below.

This Baltimore vs. St Louis betting preview is proudly sponsored by PointsBet, which has an awesome 5x $100 Risk-Free Bets promo for new users.

Who will win Orioles vs. Cardinals?

Based on advanced machine learning and data, Dimers.com has simulated Wednesday's Orioles-Cardinals MLB game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, currently gives the Cardinals a 65% chance of beating the Orioles.

More: Full Betting Analysis for Orioles vs. Cardinals

Orioles vs. Cardinals Odds

• Run Line: Cardinals -1.5 (-110), Orioles +1.5 (-105)
• Moneyline: Cardinals -225, Orioles +195
• Total: Over/Under 8 (-104/-118)

Run Line, Moneyline and Over/Under

The Cardinals are -1.5 favorites versus the Orioles, with -110 at Caesars Sportsbook the best odds currently available.

For the underdog Orioles (+1.5) to cover the run line, PointsBet has the best odds currently on offer at -105.

BetMGM currently has the best moneyline odds for the Cardinals at -225. That means you can risk $225 to win $100, for a total payout of $325, if they get the W.

Meanwhile, Caesars Sportsbook currently has the best moneyline odds for the Orioles at +195, where you can bet $100 to profit $195, earning a total payout of $295, if they win.

The Over/Under for total runs scored is set at 8 with FanDuel Sportsbook, which currently has the best odds for the Over at -104, as well as the best odds for the Under at -118.

As always, check out all the online sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Orioles (+1.5) are a 53% chance of covering the run line, while the Over/Under total of 8 runs is a 58% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Orioles vs. Cardinals

• Run Line: Orioles +1.5 @ -105 via PointsBet (53% probability)
• Moneyline: Orioles @ +195 via Caesars Sportsbook (1.0% edge)
• Total: Over 8 @ -104 via FanDuel Sportsbook (58% probability) 🔥

Any time you see a 🔥, that means it's one of Dimers' best free picks of the day across any sport.

Dimers' best bets are based on world-class simulations and wagering intelligence to serve you the best possible plays every time.

While the Cardinals are more likely to win the game, according to DimersBOT, taking the Orioles moneyline is the best option due to the 1.0% edge identified when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen here at Dimers is crucial to achieving long-term profitability.

Orioles vs. Cardinals Betting Guide

Use our interactive widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Baltimore vs. St Louis, and click or tap on See Matchup for more.

Dimers has full coverage of Wednesday's Orioles-Cardinals matchup, including pregame predictions, computer picks, and live scores.

Don't forget, DimersBOT updates often, so check this article for any changes to our betting analysis before Orioles vs. Cardinals on Wednesday May 11, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Orioles vs. Cardinals 2022 Game Info

Wednesday's game between the Cardinals and Orioles at Busch Stadium is scheduled to begin at 7:45PM ET.

• Date: Wednesday May 11, 2022
• Time: 7:45PM ET / 4:45PM PT
• Venue: Busch Stadium

Want to join an online sportsbook and start betting on MLB today? Check out the best sports betting offers in your state.

Want more MLB analysis like this?

To get more MLB betting predictions like you've just read for Orioles vs. Cardinals, all you've gotta do is visit Dimers' MLB Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find edges in the markets so we can produce the most comprehensive MLB betting previews available. We're able to do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.

Lastly, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.