Orioles vs. Athletics Prediction and Odds - Apr 21, 2022

MLB action continues on Thursday at 3:37PM ET as the Baltimore Orioles take on the Oakland Athletics at Oakland Coliseum.

Paul Blackburn (1-0, 1.80 ERA) will start on the mound for the Athletics, pitting him against Tyler Wells (0-1, 6.35 ERA) for the Orioles.

Dimers' top betting picks for Orioles vs. Athletics, as well as game predictions and best odds, are featured below.

Who will win Orioles vs. Athletics?

Using cutting-edge machine learning and data, Dimers.com has simulated Thursday's Orioles-Athletics MLB game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the Athletics a 53% chance of beating the Orioles.

More: Orioles vs. Athletics Simulated 10,000 Times

Orioles vs. Athletics Game Odds

• Run Line: Athletics -1.5 (+155), Orioles +1.5 (-178)
• Moneyline: Athletics -130, Orioles +116
• Total: Over/Under 7 (-105/+100)

Run Line, Moneyline and Over/Under

The Athletics are listed as -1.5 favorites versus the Orioles, with +155 at BetMGM the best odds currently available.

For the underdog Orioles (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -178.

DraftKings Sportsbook currently has the best moneyline odds for the Athletics at -130. That means you can risk $130 to win $100, for a total payout of $230, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Orioles at +116, where you can bet $100 to profit $116, earning a total payout of $216, if they win.

The Over/Under for total runs scored sits at 7 with FanDuel Sportsbook, which currently has the best odds for the Over at -105, while DraftKings Sportsbook currently has the best odds for the Under at +100.

As always, make sure you check all the sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Orioles (+1.5) are a 65% chance of covering the run line, while the 7-run Over/Under is a 56% chance of going Over.

More: Best Bets for Every MLB Game

Best Bets for Orioles vs. Athletics

• Run Line: Orioles +1.5 @ -178 via FanDuel Sportsbook (65% probability)
• Moneyline: Orioles @ +116 via FanDuel Sportsbook (0.8% edge)
• Total: Over 7 @ -105 via FanDuel Sportsbook (56% probability) 🔥

If you see a 🔥, that means it's one of our best bets of the day across any sport.

Dimers' best bets are based on complex simulations and wagering intelligence to serve you the best possible plays every day of the year.

While the Athletics are more likely to win the game, according to DimersBOT, betting on the Orioles moneyline is the best option because of the edge identified when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges seen on Dimers is one of the keys to achieving long-term profitability as a bettor.

Orioles vs. Athletics Probabilities

Use our dynamic widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Baltimore vs. Oakland, and click or tap on See Matchup for more.

Dimers has full betting coverage of Thursday's Orioles-Athletics matchup, including pregame predictions, top betting picks, and live win probabilities.

Remember, DimersBOT updates frequently, so check this page for the latest betting analysis before Orioles vs. Athletics on Thursday April 21, 2022.

Best Sportsbook Promo for Orioles vs. Athletics

Looking for the best sportsbook offer in America for Baltimore vs. Oakland? Join FanDuel Sportsbook today and get a risk-free first bet up to $1,000, which you can use on Thursday's Orioles-Athletics game.

Simply click or tap on this exclusive FanDuel Sportsbook link and create an account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1K on Orioles vs. Athletics. If you don't win your bet, FanDuel Sportsbook will refund it in site credit!

This offer is available to all new FanDuel Sportsbook users. How good is that!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Orioles vs. Athletics 2022 Game Info

When do the Athletics play the Orioles?

• Date: Thursday April 21, 2022
• Time: 3:37PM ET / 12:37PM PT
• Venue: Oakland Coliseum

Enjoy Dimers.com and want to keep the site free? Every time you join a sportsbook featured here, we get paid a small fee.

These fees help us keep Dimers free for all sports fans. So, if you like what you see, support us by joining one of our trusted sports betting partners today.

What other MLB games are on today?

The Orioles and Athletics aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and best bets for each and every MLB game in our MLB Bet Hub section.

Not only do we provide with you great predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

Lastly, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.