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Ole Miss vs. St. John's prediction: St. John's favored to win men's college basketball matchup [12/6/2025]

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Written by Dave Garofolo

Get Ole Miss vs St. John's predictions for college basketball Saturday.

Ole Miss-St. John's Predictions and Game Preview.
Ole Miss vs. St. John's men's college basketball prediction for Saturday, December 6, 2025.

St. John's will face Ole Miss in men's college basketball action at Madison Square Garden on Saturday, beginning at 8:00PM ET.

Based on updated simulation results, Dimers' proven college basketball model predicts St. John's as the most likely winner of the Ole Miss vs. St. John's game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Ole Miss vs. St. John's prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Saturday's NCAA basketball matchup between Ole Miss and St. John's 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives St. John's an 88% chance of defeating Ole Miss. Our predicted final score has St. John's winning 82-69.

According to our model, St. John's (-12.5) has a 53% chance of covering the spread, while the 151.5-point over/under has a 52% chance of going over.

 

Ole Miss vs. St. John's odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

Bet Type Ole Miss St. John's
Spread +12.5 (-102) -12.5 (-120)
Moneyline +700 -1050
Total o151.5 (-105) u151.5 (-110)

All odds are correct at the time of publication and are subject to change.

Ole Miss vs. St. John's picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread St. John's -12.5 -120
Moneyline Ole Miss +700
Total Over 151.5 -105

According to our men's college basketball best bets, the top play to make on this game is Over 151.5 total points.

 

Ole Miss vs. St. John's game-day updates and essential details

Saturday's men's college basketball game between St. John's and Ole Miss at Madison Square Garden is scheduled to commence at 8:00PM ET.

  • Who: Ole Miss vs. St. John's
  • Date: Saturday, December 6, 2025
  • Time: 8:00PM ET/5:00PM PT
  • Venue: Madison Square Garden

 

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Conclusion

We predict St. John's, with an 88% win probability, will likely beat Ole Miss on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Ole Miss vs. St. John's insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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