Ohio State vs. Northwestern prediction: Northwestern favored to win men's college basketball matchup [12/6/2025]

Northwestern will square off with Ohio State in men's college basketball action at Welsh-Ryan Arena on Saturday, starting at 2:00PM ET.

Based on updated simulation results, Dimers' proven college basketball model projects Northwestern as the most likely winner of the Ohio State vs. Northwestern game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Ohio State vs. Northwestern prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the outcome of Saturday's NCAA basketball matchup between Ohio State and Northwestern 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Northwestern a 61% chance of beating Ohio State. Our predicted final score has Northwestern winning 76-73.

According to our model, Northwestern (-2.5) has a 51% chance of covering the spread, while the 153.5-point over/under has a 55% chance of staying under.

Ohio State vs. Northwestern odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Ohio State vs. Northwestern picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: