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Northwestern vs. Butler prediction: Butler favored to win men's college basketball matchup [12/20/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Northwestern vs Butler predictions for college basketball Saturday.
Butler will take on Northwestern in men's college basketball action at Gainbridge Fieldhouse on Saturday, starting at 4:00 PM ET.
Based on the latest simulations, Dimers' advanced college basketball model predicts Butler as the most likely winner of the Northwestern vs. Butler game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Northwestern vs. Butler prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the outcome of Saturday's NCAA basketball game between Northwestern and Butler 10,000 times as part of our men's college basketball predictions coverage.
Our leading predictive model gives Butler a 62% chance of defeating Northwestern. Our predicted final score has Butler winning 80-77.
According to our model, Northwestern (+3.5) has a 53% chance of covering the spread, while the over/under total of 154.5 points has a 52% chance of going over.
Northwestern vs. Butler odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Northwestern | Butler |
|---|---|---|
| Spread | +3.5 (-102) | -3.5 (-118) |
| Moneyline | +160 | -188 |
| Total | o154.5 (-105) | u154.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Northwestern vs. Butler picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Northwestern +3.5 | -102 |
| Moneyline | Northwestern | +160 |
| Total | Over 154.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is Northwestern +3.5 at the spread.
Northwestern vs. Butler game-day updates and essential details
Saturday's men's college basketball game between Butler and Northwestern at Gainbridge Fieldhouse is scheduled to begin at 4:00 PM ET.
- Who: Northwestern vs. Butler
- Date: Saturday, December 20, 2025
- Time: 4:00 PM ET/1:00PM PT
- Venue: Gainbridge Fieldhouse
Conclusion
We predict Butler, with a 62% win probability, will likely beat Northwestern on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Northwestern vs. Butler insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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