Northwestern vs. Butler prediction: Butler favored to win men's college basketball matchup [12/20/2025]

Butler and Northwestern will meet in men's college basketball action at Gainbridge Fieldhouse on Saturday, with tipoff at 4:00 PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts Butler as the most likely winner of the Northwestern vs. Butler game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Northwestern vs. Butler prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Saturday's NCAA basketball game between Northwestern and Butler 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Butler a 59% chance of defeating Northwestern. Our predicted final score has Butler winning 80-78.

According to our model, the bookmakers have got it right, and Northwestern and Butler each have a 50% chance of covering the spread, while the 157.5-point over/under has a 52% chance of going over.

Northwestern vs. Butler odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Northwestern vs. Butler picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: