Northeastern vs. Syracuse prediction: Syracuse favored to win men's college basketball matchup [12/20/2025]

Syracuse and Northeastern will meet in men's college basketball action at JMA Wireless Dome on Saturday, with tipoff at 4:00 PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts Syracuse as the most likely winner of the Northeastern vs. Syracuse game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Northeastern vs. Syracuse prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Saturday's NCAA basketball game between Northeastern and Syracuse 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Syracuse a 90% chance of defeating Northeastern. Our predicted final score has Syracuse winning 78-64.

According to our model, Northeastern (+14.5) has a 53% chance of covering the spread, while the over/under total of 143.5 points has an equal 50-50 chance of hitting.

Northeastern vs. Syracuse odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Northeastern vs. Syracuse picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: