North Texas vs. Santa Clara prediction: Santa Clara favored to win men's college basketball matchup [12/17/2025]

Men's college basketball action continues on Wednesday at 9:00 PM ET as North Texas takes on the favored Santa Clara in men's college basketball action at Kaiser Permanente Arena.

Based on the latest simulations, Dimers' advanced college basketball model predicts Santa Clara as the most likely winner of the North Texas vs. Santa Clara game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

North Texas vs. Santa Clara prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Wednesday's NCAA basketball game between North Texas and Santa Clara 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Santa Clara a 91% chance of defeating North Texas. Our predicted final score has Santa Clara winning 79-64.

According to our model, Santa Clara (-11.5) has a 58% chance of covering the spread, while the over/under total of 141.5 points has a 54% chance of going over.

North Texas vs. Santa Clara odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

North Texas vs. Santa Clara picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: