Niagara vs. Siena prediction: Siena favored to win men's college basketball matchup [12/5/2025]

Men's college basketball action continues on Friday at 7:00PM ET as Niagara squares off with Siena in men's college basketball action at MVP Arena.

Based on the latest simulation results, Dimers' proven college basketball model predicts Siena as the most likely winner of the Niagara vs. Siena game.

This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Niagara vs. Siena prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the result of Friday's NCAA basketball game between Niagara and Siena 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Siena a 92% chance of defeating Niagara. Our predicted final score has Siena winning 74-60.

According to our model, Siena (-12.5) has a 55% chance of covering the spread, while the 130.5-point over/under has a 56% chance of going over.

Niagara vs. Siena odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Niagara vs. Siena picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: