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Yankees vs. Astros prediction: Yankees favored to win Friday's MLB matchup [4/24/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get New York Yankees vs Houston Astros predictions for MLB Friday.
The Houston Astros will face the New York Yankees in MLB action at Daikin Park on Friday, commencing at 8:10 PM ET.
Lance McCullers (1-1, 6.20 ERA) will start on the mound for the Astros, pitting him against Will Warren (2-0, 2.49 ERA) for the Yankees.
Based on the latest simulations, Dimers' proven MLB model projects the Yankees as the most likely winner of the Yankees vs. Astros game.
This article offers a closer look at Friday's matchup, including best bets and picks.
Yankees vs. Astros prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the outcome of Friday's MLB matchup between the Yankees and Astros, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Yankees a 56% chance of beating the Astros.
According to our model, the Astros (+1.5) have a 56% chance of covering the run line, while the over/under total of nine runs has a 54% chance of going over.
Yankees vs. Astros odds [4/24/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Yankees | Astros |
|---|---|---|
| Run Line | -1.5 (+108) | +1.5 (-120) |
| Moneyline | -154 | +130 |
| Total | o9 (-105) | u9 (+100) |
All odds are correct at the time of publication and are subject to change.
Yankees vs. Astros picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Astros +1.5 | -120 |
| Moneyline | Astros | +130 |
| Total | Over 9 | -105 |
According to our MLB best bets, the top play to make on this game is Over 9 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Yankees vs. Astros game-day updates and essential details
Friday's MLB game between the Astros and Yankees at Daikin Park is scheduled to start at 8:10 PM ET.
- Who: New York Yankees vs. Houston Astros
- Date: Friday, April 24, 2026
- Time: 8:10 PM ET/5:10PM PT
- Venue: Daikin Park
Conclusion
We predict the Yankees, with a 56% win probability, will likely beat the Astros in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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