Morehead State vs. Southern Indiana prediction: Morehead State favored to win men's college basketball matchup [12/20/2025]

Southern Indiana and Morehead State will lock horns in men's college basketball action at Liberty Arena on Saturday, with tipoff at 4:30 PM ET.

Based on updated simulations, Dimers' proven college basketball model projects Morehead State as the most likely winner of the Morehead State vs. Southern Indiana game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Morehead State vs. Southern Indiana prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the result of Saturday's NCAA basketball matchup between Morehead State and Southern Indiana 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Morehead State a 57% chance of beating Southern Indiana. Our predicted final score has Morehead State winning 75-73.

According to our model, Morehead State (-1.5) has a 51% chance of covering the spread, while the over/under total of 147.5 points has a 52% chance of going over.

Morehead State vs. Southern Indiana odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Morehead State vs. Southern Indiana picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: