MLB picks today: Wednesday's MLB best bets include Yankees vs. Orioles play [5/13/2026]

Yankees vs. Orioles over 6.5 runs (+100)

• Edge: 8.5%
• Probability: 58.5%
• Matchup: Yankees vs. Orioles (1:05PM ET, Wednesday)

Our model has identified value on over 6.5 runs in Yankees vs. Orioles at +100 odds. A 58.5% probability produces an edge of 8.5%, making this the strongest play for today's MLB slate.

Diamondbacks vs. Rangers over 8.5 runs (+102)

• Edge: 6.3%
• Probability: 55.8%
• Matchup: Diamondbacks vs. Rangers (8:05PM ET, Wednesday)

Diamondbacks vs. Rangers over 8.5 runs carries a 6.3% edge and a probability of 55.8% at +102 odds, according to our model.

Rockies vs. Pirates over 8.5 runs (+102)

• Edge: 6.1%
• Probability: 55.6%
• Matchup: Rockies vs. Pirates (6:40PM ET, Wednesday)

Rockies vs. Pirates over 8.5 runs at +102 odds shows a 6.1% edge, supported by a 55.6% probability in simulations.

Angels vs. Guardians over 6.5 runs (-127)

• Edge: 6.1%
• Probability: 62.1%
• Matchup: Angels vs. Guardians (1:10PM ET, Wednesday)

A 6.1% edge and 62.1% probability make Angels vs. Guardians over 6.5 runs at a value play in the Angels vs. Guardians matchup, per our model.

Padres vs. Brewers over 7.5 runs (+130)

• Edge: 5.9%
• Probability: 49.4%
• Matchup: Padres vs. Brewers (7:40PM ET, Wednesday)

Padres vs. Brewers over 7.5 runs at +130 odds presents a 5.9% edge, with simulations resulting in a probability of 49.4%.

Royals vs. White Sox over 7.5 runs (-115)

• Edge: 5.3%
• Probability: 58.8%
• Matchup: Royals vs. White Sox (7:40PM ET, Wednesday)

Our model finds value on over 7.5 runs in Royals vs. White Sox at -115 odds, supported by an edge of 5.3%.

Cubs vs. Braves over 8.5 runs (-106)

• Edge: 4.7%
• Probability: 56.2%
• Matchup: Cubs vs. Braves (7:15PM ET, Wednesday)

Our model has uncovered value on Cubs vs. Braves over 8.5 runs at -106 odds. A 56.2% probability produces a 4.7% edge, making this a strong play for today's MLB action.

Marlins vs. Twins over 8.5 runs (-102)

• Edge: 4.6%
• Probability: 55.1%
• Matchup: Marlins vs. Twins (7:40PM ET, Wednesday)

A 4.6% edge on a 55.1% probability makes over 8.5 runs at -102 odds a solid value play in today's Marlins vs. Twins matchup.

Rays vs. Blue Jays over 7.5 runs (+102)

• Edge: 4.5%
• Probability: 54%
• Matchup: Rays vs. Blue Jays (7:07PM ET, Wednesday)

Our model projects value on over 7.5 runs at +102 odds. A 54% probability produces a 4.5% edge, making the over the favorable side in Saturday’s matchup.

Phillies vs. Red Sox over 8.5 runs (-117)

• Edge: 3.9%
• Probability: 57.9%
• Matchup: Phillies vs. Red Sox (6:45PM ET, Wednesday)

Rounding out our top 10 bets, Phillies vs. Red Sox over 8.5 runs at -117 odds shows a 57.9% probability and a 3.9% edge.

MLB best bets summary: Wednesday, 5/13/2026

As of 7:02AM ET, here are our top MLB bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Yankees vs. Orioles	Over 6.5 Runs	+100 @ polymarket	8.5%	58.5%
Diamondbacks vs. Rangers	Over 8.5 Runs	+102 @ polymarket	6.3%	55.8%
Rockies vs. Pirates	Over 8.5 Runs	+102 @ polymarket	6.1%	55.6%
Angels vs. Guardians	Over 6.5 Runs	-127 @ polymarket	6.1%	62.1%
Padres vs. Brewers	Over 7.5 Runs	+130 @ polymarket	5.9%	49.4%
Royals vs. White Sox	Over 7.5 Runs	-115 @ polymarket	5.3%	58.8%
Cubs vs. Braves	Over 8.5 Runs	-106 @ polymarket	4.7%	56.2%
Marlins vs. Twins	Over 8.5 Runs	-102 @ polymarket	4.6%	55.1%
Rays vs. Blue Jays	Over 7.5 Runs	+102 @ polymarket	4.5%	54%
Phillies vs. Red Sox	Over 8.5 Runs	-117 @ polymarket	3.9%	57.9%

List of upcoming MLB games to bet on [5/13/2026]

• Yankees vs. Orioles (1:05PM ET, Wednesday)
• Angels vs. Guardians (1:10PM ET, Wednesday)
• Rockies vs. Pirates (6:40PM ET, Wednesday)
• Nationals vs. Reds (6:40PM ET, Wednesday)
• Phillies vs. Red Sox (6:45PM ET, Wednesday)
• Rays vs. Blue Jays (7:07PM ET, Wednesday)
• Tigers vs. Mets (7:10PM ET, Wednesday)
• Cubs vs. Braves (7:15PM ET, Wednesday)
• Padres vs. Brewers (7:40PM ET, Wednesday)
• Marlins vs. Twins (7:40PM ET, Wednesday)
• Royals vs. White Sox (7:40PM ET, Wednesday)
• D-Backs vs. Rangers (8:05PM ET, Wednesday)
• Mariners vs. Astros (8:10PM ET, Wednesday)
• Cardinals vs. Athletics (9:40PM ET, Wednesday)
• Giants vs. Dodgers (10:10PM ET, Wednesday)

Conclusion

Our MLB best bets are locked and loaded for May 13, 2026, featuring plays such as over 6.5 runs in the Yankees vs. Orioles matchup and over 8.5 runs in the Diamondbacks vs. Rangers matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.