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MLB picks today: Tuesday's MLB best bets include White Sox vs. Diamondbacks play [4/21/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get MLB picks today and best bets for Tuesday, April 21, 2026.
Today’s MLB picks for April 21, 2026 are here, with White Sox vs. Diamondbacks and Dodgers vs. Giants among the top plays identified by our model across Tuesday’s MLB schedule.
Dimers’ predictive analytics engine runs 24/7, going over the latest baseball odds to find real betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of MLB best bets today [4/21, updated 8:33AM ET]
Below, you’ll find today’s best baseball bets, ranked by edge for Tuesday, April 21, 2026.
White Sox vs. Diamondbacks over 9 runs (-108)
- Edge: 4.7%
- Probability: 56.6%
- Matchup: White Sox vs. Diamondbacks (9:40PM ET, Tuesday)
Our model has identified value on over 9 runs in White Sox vs. Diamondbacks at -108 odds. A 56.6% probability produces an edge of 4.7%, making this the strongest play for today's MLB slate.
Dodgers vs. Giants over 7 runs (-102)
- Edge: 3.9%
- Probability: 54.4%
- Matchup: Dodgers vs. Giants (9:45PM ET, Tuesday)
Dodgers vs. Giants over 7 runs carries a 3.9% edge and a probability of 54.4% at -102 odds, according to our model.
Astros vs. Guardians over 8 runs (-115)
- Edge: 3.3%
- Probability: 56.8%
- Matchup: Astros vs. Guardians (6:10PM ET, Tuesday)
Astros vs. Guardians over 8 runs at -115 odds shows a 3.3% edge, supported by a 56.8% probability in simulations.
Blue Jays vs. Angels over 9 runs (-102)
- Edge: 2.0%
- Probability: 52.5%
- Matchup: Blue Jays vs. Angels (9:38PM ET, Tuesday)
A 2.0% edge and 52.5% probability make Blue Jays vs. Angels over 9 runs at a value play in the Blue Jays vs. Angels matchup, per our model.
MLB best bets summary: Tuesday, 4/21/2026
As of 8:33AM ET, here are our top MLB bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| White Sox vs. Diamondbacks | Over 9 Runs | -108 @ DraftKings | 4.7% | 56.6% |
| Dodgers vs. Giants | Over 7 Runs | -102 @ DraftKings | 3.9% | 54.4% |
| Astros vs. Guardians | Over 8 Runs | -115 @ BetMGM | 3.3% | 56.8% |
| Blue Jays vs. Angels | Over 9 Runs | -102 @ DraftKings | 2.0% | 52.5% |
List of upcoming MLB games to bet on [4/21/2026]
- Astros vs. Guardians (6:10PM ET, Tuesday)
- Brewers vs. Tigers (6:40PM ET, Tuesday)
- Cardinals vs. Marlins (6:40PM ET, Tuesday)
- Reds vs. Rays (6:40PM ET, Tuesday)
- Yankees vs. Red Sox (6:45PM ET, Tuesday)
- Braves vs. Nationals (6:45PM ET, Tuesday)
- Twins vs. Mets (7:10PM ET, Tuesday)
- Phillies vs. Cubs (7:40PM ET, Tuesday)
- Orioles vs. Royals (7:40PM ET, Tuesday)
- Pirates vs. Rangers (8:05PM ET, Tuesday)
- Blue Jays vs. Angels (9:38PM ET, Tuesday)
- Athletics vs. Mariners (9:40PM ET, Tuesday)
- White Sox vs. D-Backs (9:40PM ET, Tuesday)
- Dodgers vs. Giants (9:45PM ET, Tuesday)
Conclusion
Our MLB best bets are locked and loaded for April 21, 2026, featuring plays such as over 9 runs in the White Sox vs. Diamondbacks matchup and over 7 runs in the Dodgers vs. Giants matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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