Jun 4, 2026
MLB picks today: Thursday's MLB best bets include Dodgers vs. Diamondbacks play [6/4/2026]
Read Article MLB picks today: Tuesday's MLB best bets include White Sox vs. Diamondbacks play [4/21/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get MLB picks today and best bets for Tuesday, April 21, 2026.
Today’s MLB picks for April 21, 2026 are here, with White Sox vs. Diamondbacks and Pirates vs. Rangers among the top plays identified by our model across Tuesday’s MLB slate.
Dimers’ predictive analytics engine runs 24/7, going over the latest baseball odds to unearth legitimate betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of MLB best bets tonight [4/21, updated 9:35PM ET]
Below, you’ll find today’s top 10 baseball bets, ranked by edge for Tuesday, April 21, 2026.
White Sox vs. Diamondbacks over 9 runs (-105)
- Edge: 4.4%
- Probability: 55.6%
- Matchup: White Sox vs. Diamondbacks (9:40PM ET, Tuesday)
Our model has identified value on over 9 runs in White Sox vs. Diamondbacks at -105 odds. A 55.6% probability produces an edge of 4.4%, making this the strongest play for today's MLB slate.
Pirates vs. Rangers over 8 runs (-122)
- Edge: 3.2%
- Probability: 58.2%
- Matchup: Pirates vs. Rangers (8:05PM ET, Wednesday)
Pirates vs. Rangers over 8 runs carries a 3.2% edge and a probability of 58.2% at -122 odds, according to our model.
Padres vs. Rockies over 11.5 runs (-105)
- Edge: 3.1%
- Probability: 54.3%
- Matchup: Padres vs. Rockies (8:40PM ET, Wednesday)
Padres vs. Rockies over 11.5 runs at -105 odds shows a 3.1% edge, supported by a 54.3% probability in simulations.
Braves vs. Nationals over 9 runs (-105)
- Edge: 3.1%
- Probability: 54.3%
- Matchup: Braves vs. Nationals (6:45PM ET, Wednesday)
A 3.1% edge and 54.3% probability make Braves vs. Nationals over 9 runs at a value play in the Braves vs. Nationals matchup, per our model.
Orioles vs. Royals over 9 runs (-108)
- Edge: 2.9%
- Probability: 54.9%
- Matchup: Orioles vs. Royals (2:10PM ET, Wednesday)
Orioles vs. Royals over 9 runs at -108 odds presents a 2.9% edge, with simulations resulting in a probability of 54.9%.
Red Sox ML (+124)
- Edge: 2.8%
- Probability: 47.4%
- Matchup: Yankees vs. Red Sox (6:45PM ET, Wednesday)
Our model finds value on Red Sox to win at +124 odds, supported by an edge of 2.8%.
Astros ML (+120)
- Edge: 2.5%
- Probability: 47.9%
- Matchup: Astros vs. Guardians (1:10PM ET, Wednesday)
Our model has uncovered value on Astros ML at +120 odds. A 47.9% probability produces a 2.5% edge, making this a strong play for today's MLB action.
Red Sox +1.5 (-137)
- Edge: 2.4%
- Probability: 60.2%
- Matchup: Yankees vs. Red Sox (6:45PM ET, Wednesday)
A 2.4% edge on a 60.2% probability makes Red Sox +1.5 at -137 odds a solid value play in today's Yankees vs. Red Sox matchup.
Blue Jays vs. Angels over 9 runs (-105)
- Edge: 2.4%
- Probability: 53.6%
- Matchup: Blue Jays vs. Angels (9:38PM ET, Tuesday)
Our model projects value on over 9 runs at -105 odds. A 53.6% probability produces a 2.4% edge, making the over the favorable side in Saturday’s matchup.
Blue Jays ML (+135)
- Edge: 2.2%
- Probability: 44.7%
- Matchup: Blue Jays vs. Angels (3:07PM ET, Wednesday)
Rounding out our top 10 bets, Blue Jays to defeat Angels at +135 odds shows a 44.7% probability and a 2.2% edge.
MLB best bets summary: Tuesday, 4/21/2026
As of 9:35PM ET, here are our top MLB bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| White Sox vs. Diamondbacks | Over 9 Runs | -105 @ DraftKings | 4.4% | 55.6% |
| Pirates vs. Rangers | Over 8 Runs | -122 @ FanDuel | 3.2% | 58.2% |
| Padres vs. Rockies | Over 11.5 Runs | -105 @ DraftKings | 3.1% | 54.3% |
| Braves vs. Nationals | Over 9 Runs | -105 @ BetMGM | 3.1% | 54.3% |
| Orioles vs. Royals | Over 9 Runs | -108 @ DraftKings | 2.9% | 54.9% |
| Yankees vs. Red Sox | Red Sox ML | +124 @ FanDuel | 2.8% | 47.4% |
| Astros vs. Guardians | Astros ML | +120 @ BetMGM | 2.5% | 47.9% |
| Yankees vs. Red Sox | Red Sox +1.5 | -137 @ FanDuel | 2.4% | 60.2% |
| Blue Jays vs. Angels | Over 9 Runs | -105 @ BetMGM | 2.4% | 53.6% |
| Blue Jays vs. Angels | Blue Jays ML | +135 @ DraftKings | 2.2% | 44.7% |
List of upcoming MLB games to bet on [4/21/2026]
- Blue Jays vs. Angels (9:38PM ET, Tuesday)
- Athletics vs. Mariners (9:40PM ET, Tuesday)
- White Sox vs. D-Backs (9:40PM ET, Tuesday)
- Dodgers vs. Giants (9:45PM ET, Tuesday)
- Cardinals vs. Marlins (12:10PM ET, Wednesday)
- Astros vs. Guardians (1:10PM ET, Wednesday)
- Reds vs. Rays (1:10PM ET, Wednesday)
- Orioles vs. Royals (2:10PM ET, Wednesday)
- Blue Jays vs. Angels (3:07PM ET, Wednesday)
- Athletics vs. Mariners (4:10PM ET, Wednesday)
- Brewers vs. Tigers (6:40PM ET, Wednesday)
- Braves vs. Nationals (6:45PM ET, Wednesday)
- Yankees vs. Red Sox (6:45PM ET, Wednesday)
- Pirates vs. Rangers (8:05PM ET, Wednesday)
- Padres vs. Rockies (8:40PM ET, Wednesday)
Conclusion
Our MLB best bets are locked and loaded for April 21, 2026, featuring plays such as over 9 runs in the White Sox vs. Diamondbacks matchup and over 8 runs in the Pirates vs. Rangers matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
Advertiser disclosure
