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Astros vs. Guardians Prediction, Picks and Odds
Our detailed prediction and analysis for the Astros vs. Guardians MLB game on April 22, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
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MLB
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Apr 22, 5:10PM Progressive Field
Apr 22, 5:10PM Progressive Field
In-Play ProbabilitiesIn-Play
Game PredictionsPre-Game
Bets
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | R | H | E | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Astros | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 6 | 1 |
Guardians | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 0 |
Live Probabilities
Moneyline
Over / Under
Run Line
Win %
100%
0%
Win Probability
Last At Bat
Outs
Brayan Rocchio flies out to center field to Daniel Johnson.
Quick Box Score
Hitting
Pitching
| No. | Player | Pos | AB | R | H | RBI | HR | BB | SO | AVG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | C. Correa | SS | 4 | 1 | 1 | 0 | 0 | 0 | 1 | .250 | 0.750 |
| 2 | Y. Alvarez | DH | 4 | 1 | 3 | 2 | 1 | 0 | 0 | .750 | 2.250 |
| 3 | J. Altuve | 2B | 4 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | 0.000 |
| 4 | C. Walker | 1B | 3 | 0 | 1 | 0 | 0 | 1 | 0 | .333 | 0.833 |
| 5 | I. Paredes | 3B | 4 | 0 | 1 | 0 | 0 | 0 | 1 | .250 | 0.500 |
| 6 | C. Smith | RF | 4 | 0 | 0 | 0 | 0 | 0 | 2 | .000 | 0.000 |
| 7 | D. Johnson | CF | 4 | 0 | 0 | 0 | 0 | 0 | 1 | .000 | 0.000 |
| 8 | C. Vázquez | C | 3 | 0 | 0 | 0 | 0 | 1 | 1 | .000 | 0.250 |
| 9 | B. Matthews | LF | 2 | 0 | 0 | 0 | 0 | 1 | 0 | .000 | 0.333 |
| No. | Player | Pos | AB | R | H | RBI | HR | BB | SO | AVG | OPS |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | S. Kwan | CF | 3 | 0 | 1 | 0 | 0 | 1 | 0 | .333 | 0.833 |
| 2 | C. DeLauter | RF | 4 | 0 | 2 | 0 | 0 | 0 | 0 | .500 | 1.000 |
| 3 | J. Ramírez | DH | 4 | 0 | 1 | 0 | 0 | 0 | 2 | .250 | 0.500 |
| 4 | R. Hoskins | 1B | 1 | 0 | 0 | 0 | 0 | 0 | 1 | .000 | 0.000 |
| 5 | G. Valera | LF | 4 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | 0.000 |
| 6 | D. Schneemann | 3B | 3 | 0 | 1 | 0 | 0 | 1 | 2 | .333 | 0.833 |
| 7 | A. Martínez | PH | 1 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | 0.000 |
| 8 | B. Naylor | C | 3 | 0 | 0 | 0 | 0 | 1 | 1 | .000 | 0.250 |
| 9 | B. Rocchio | SS | 4 | 0 | 0 | 0 | 0 | 0 | 0 | .000 | 0.000 |
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Astros vs. Guardians: Detailed Breakdown
Matchup Overview
- Teams: Astros vs. Guardians
- Date: Wednesday, April 22, 2026
- Time: 1:10 PM ET
- Venue: Progressive Field
Current Betting Odds
- Spread: Guardians favored at -1.5
- Total (Over/Under): 8.5
- Moneyline Odds: Astros +147, Guardians -147
Dimers' Win Probabilities
- Astros: 59%
- Guardians: 41%
Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.
Our Prediction: Who Wins?
After extensive simulations, our model gives the Astros a win probability of 59%, while the Guardians have a win probability of 41%. Discover the best spread, over/under, and moneyline odds for the game on this page.
Summary
According to our analysis, the Astros are more likely to beat the Guardians in the MLB game at Progressive Field on Wednesday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.
Our Astros vs. Guardians predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.
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For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.
