Mets vs. Padres prediction: San Diego favored to win Friday's MLB matchup [6/5/2026]

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Written by Dave Garofolo

Get New York Mets vs San Diego Padres predictions for MLB Friday.

New York Mets-San Diego Padres Predictions and Game Preview.
New York Mets vs. San Diego Padres MLB prediction for Friday, June 5, 2026.

MLB action continues on Friday at 9:40 PM ET as the New York Mets take on the San Diego Padres at Petco Park.

Michael King (4-4, 3.18 ERA) will get the ball for the Padres, while the Mets are going with Christian Scott (1-0, 2.97 ERA).

Based on the latest simulations, Dimers' advanced MLB model projects the Padres as the most likely winner of the Mets vs. Padres game.

This article offers an expanded analysis of Friday's matchup, including best bets and picks.

Mets vs. Padres prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Friday's MLB matchup between the Mets and Padres, forming part of our MLB predictions coverage.

Our famous predictive model gives the Padres a 52.4% chance of beating the Mets.

According to our model, the Mets (+1.5) have a 65.7% chance of covering the run line, while the over/under total of 7.5 runs has a 50.7% chance of staying under.

 

Mets vs. Padres odds [6/5/2026]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type Mets Padres
Run Line +1.5 (-200) -1.5 (+168)
Moneyline +110 -126
Total o7.5 (+104) u7.5 (-128)

All odds are correct at the time of publication and are subject to change.

Mets vs. Padres picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Run Line Mets +1.5 -200
Moneyline Mets +110
Total Over 7.5 +104

According to our MLB best bets, the top play to make on this game is Over 7.5 total runs.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

 

Mets vs. Padres game-day updates and essential details

Friday's MLB matchup between the Padres and Mets at Petco Park is scheduled to commence at 9:40 PM ET.

Conclusion

We predict the Padres, with a 52.4% win probability, will likely beat the Mets in Friday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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