White Sox vs. D-Backs Prediction, Picks and Odds

Our detailed prediction and analysis for the White Sox vs. D-Backs MLB game on April 21, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
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MLB
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MLB sport icon
MLB
White Sox
11
5
Apr 21, 9:40 PM ET Chase Field
D-Backs
Apr 21, 9:40 PM ET Chase Field
1 2 3 4 5 6 7 8 9 RHE
White Sox
4 3 0 0 1 0 0 0 3 11 14 0
D-Backs
0 0 0 1 1 0 0 0 3 5 8 0
Live Probabilities
Win %
  • White Sox
    100%
  • D-Backs
    0%
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Adrian Del Castillo flies out to deep center field to Tristan Peters.
Quick Box Score
White Sox Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 A. Benintendi DH6120001.3330.666
2 M. Murakami 1B5231110.6001.867
3 M. Vargas 3B4211110.2501.400
4 C. Montgomery SS5223102.4001.600
5 E. Pereira RF3101002.0000.200
6 S. Antonacci LF5123100.4001.800
7 C. Meidroth 2B3210021.3330.933
8 T. Peters CF5030001.6001.200
9 R. McGuire C2001021.0000.500
D-Backs Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 K. Marte 2B4010011.2500.650
2 C. Carroll RF3000023.0000.400
3 G. Perdomo SS3110020.3331.600
4 A. Del Castillo C5000001.0000.000
5 L. Gurriel LF3001010.0000.250
6 J. Fernandez DH4110001.2500.500
7 N. Arenado 3B3120010.6671.750
8 I. Vargas 1B4113100.2501.250
9 A. Thomas CF4121100.5001.750

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White Sox vs. D-Backs: Detailed Breakdown

Matchup Overview

  • Teams: White Sox vs. D-Backs
  • Date: Tuesday, April 21, 2026
  • Time: 9:40 PM ET
  • Venue: Chase Field

Current Betting Odds

  • Spread: D-Backs favored at -1.5
  • Total (Over/Under): 9.5
  • Moneyline Odds: White Sox +141, D-Backs -140

Dimers' Win Probabilities

  • White Sox: 41%
  • D-Backs: 59%

Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the White Sox a win probability of 41%, while the D-Backs have a win probability of 59%. Discover the best spread, over/under, and moneyline odds for the game on this page.

Summary

According to our analysis, the D-Backs are more likely to beat the White Sox in the MLB game at Chase Field on Wednesday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our White Sox vs. D-Backs predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.