MLB picks today: Saturday's MLB best bets include Rockies vs. Diamondbacks play [5/23/2026]

Updated: May 23, 2026, 3:55 PM ET | First published: May 23, 2026, 12:07 AM ET

Written by Dave Garofolo, Content Producer

Get MLB picks today and best bets for Saturday, May 23, 2026.

MLB Best Bets. — These MLB betting picks for May 23, 2026, are based on the latest odds and probabilities for Saturday's games.

Today’s MLB picks for May 23, 2026 are here, with Rockies vs. Diamondbacks and Astros vs. Cubs among the top plays identified by our model across Saturday’s MLB play.

Dimers’ predictive analytics engine runs 24/7, searching the latest baseball odds to uncover real betting edges. The result? Data-backed plays that help Dimers Pro members make smarter decisions.

List of MLB best bets today [5/23, updated 3:55PM ET]

Below, you’ll find today’s top 10 baseball bets, ranked by edge for Saturday, May 23, 2026.

Rockies vs. Diamondbacks over 9.5 runs (+113)

Edge: 8.5%
Probability: 55.5%
Matchup: Rockies vs. Diamondbacks (10:10PM ET, Saturday)

Our model has identified value on over 9.5 runs in Rockies vs. Diamondbacks at +113 odds. A 55.5% probability produces an edge of 8.5%, making this the strongest play for today's MLB slate.

Astros vs. Cubs over 8.5 runs (+122)

Edge: 6.8%
Probability: 51.8%
Matchup: Astros vs. Cubs (2:20PM ET, Sunday)

Astros vs. Cubs over 8.5 runs carries a 6.8% edge and a probability of 51.8% at +122 odds, according to our model.

Twins vs. Red Sox over 7.5 runs (-106)

Edge: 6.7%
Probability: 58.2%
Matchup: Twins vs. Red Sox (4:10PM ET, Saturday)

Twins vs. Red Sox over 7.5 runs at -106 odds shows a 6.7% edge, supported by a 58.2% probability in simulations.

Nationals vs. Braves over 8.5 runs (-102)

Edge: 5.7%
Probability: 56.2%
Matchup: Nationals vs. Braves (4:10PM ET, Saturday)

A 5.7% edge and 56.2% probability make Nationals vs. Braves over 8.5 runs at a value play in the Nationals vs. Braves matchup, per our model.

Mariners vs. Royals over 8.5 runs (+111)

Edge: 5.5%
Probability: 53%
Matchup: Mariners vs. Royals (4:10PM ET, Saturday)

Mariners vs. Royals over 8.5 runs at +111 odds presents a 5.5% edge, with simulations resulting in a probability of 53%.

Pirates vs. Blue Jays over 7.5 runs (+100)

Edge: 5.2%
Probability: 55.2%
Matchup: Pirates vs. Blue Jays (12:15PM ET, Sunday)

Our model finds value on over 7.5 runs in Pirates vs. Blue Jays at +100 odds, supported by an edge of 5.2%.

Twins vs. Red Sox over 8 runs (+100)

Edge: 4.7%
Probability: 54.7%
Matchup: Twins vs. Red Sox (1:35PM ET, Sunday)

Our model has uncovered value on Twins vs. Red Sox over 8 runs at +100 odds. A 54.7% probability produces a 4.7% edge, making this a strong play for today's MLB action.

Mets vs. Marlins over 7.5 runs (-111)

Edge: 4.6%
Probability: 57.1%
Matchup: Mets vs. Marlins (4:10PM ET, Saturday)

A 4.6% edge on a 57.1% probability makes over 7.5 runs at -111 odds a solid value play in today's Mets vs. Marlins matchup.

Rangers vs. Angels over 7.5 runs (-104)

Edge: 4.6%
Probability: 55.6%
Matchup: Rangers vs. Angels (10:05PM ET, Saturday)

Our model projects value on over 7.5 runs at -104 odds. A 55.6% probability produces a 4.6% edge, making the over the favorable side in Saturday’s matchup.

Dodgers vs. Brewers over 8 runs (-115)

Edge: 4.0%
Probability: 57.4%
Matchup: Dodgers vs. Brewers (2:10PM ET, Sunday)

Rounding out our top 10 bets, Dodgers vs. Brewers over 8 runs at -115 odds shows a 57.4% probability and a 4.0% edge.

MLB best bets summary: Saturday, 5/23/2026

As of 3:55PM ET, here are our top MLB bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Rockies vs. Diamondbacks	Over 9.5 Runs	+113 @ Polymarket	8.5%	55.5%
Astros vs. Cubs	Over 8.5 Runs	+122 @ Polymarket	6.8%	51.8%
Twins vs. Red Sox	Over 7.5 Runs	-106 @ Polymarket	6.7%	58.2%
Nationals vs. Braves	Over 8.5 Runs	-102 @ Polymarket	5.7%	56.2%
Mariners vs. Royals	Over 8.5 Runs	+111 @ Polymarket	5.5%	53%
Pirates vs. Blue Jays	Over 7.5 Runs	+100 @ Polymarket	5.2%	55.2%
Twins vs. Red Sox	Over 8 Runs	+100 @ Fanatics	4.7%	54.7%
Mets vs. Marlins	Over 7.5 Runs	-111 @ Polymarket	4.6%	57.1%
Rangers vs. Angels	Over 7.5 Runs	-104 @ Kalshi	4.6%	55.6%
Dodgers vs. Brewers	Over 8 Runs	-115 @ FanDuel	4.0%	57.4%

List of upcoming MLB games to bet on [5/23/2026]

Guardians vs. Phillies (4:05PM ET, Saturday)
White Sox vs. Giants (4:05PM ET, Saturday)
Tigers vs. Orioles (4:05PM ET, Saturday)
Mariners vs. Royals (4:10PM ET, Saturday)
Mets vs. Marlins (4:10PM ET, Saturday)
Nationals vs. Braves (4:10PM ET, Saturday)
Twins vs. Red Sox (4:10PM ET, Saturday)
Dodgers vs. Brewers (7:15PM ET, Saturday)
Athletics vs. Padres (9:40PM ET, Saturday)
Rangers vs. Angels (10:05PM ET, Saturday)
Rockies vs. D-Backs (10:10PM ET, Saturday)
Pirates vs. Blue Jays (12:15PM ET, Sunday)
Guardians vs. Phillies (1:35PM ET, Sunday)
Twins vs. Red Sox (1:35PM ET, Sunday)
Rays vs. Yankees (1:35PM ET, Sunday)
Cardinals vs. Reds (1:40PM ET, Sunday)
Mariners vs. Royals (2:10PM ET, Sunday)
Dodgers vs. Brewers (2:10PM ET, Sunday)
Astros vs. Cubs (2:20PM ET, Sunday)

Conclusion

Our MLB best bets are locked and loaded for May 23, 2026, featuring plays such as over 9.5 runs in the Rockies vs. Diamondbacks matchup and over 8.5 runs in the Astros vs. Cubs matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are based on current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.

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Written by

Dave Garofolo

Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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