MLB picks today: Memorial Day MLB best bets include Diamondbacks vs. Giants play [5/25/2026]

Diamondbacks vs. Giants over 7.5 runs (+102)

• Edge: 6.3%
• Probability: 55.8%
• Matchup: Diamondbacks vs. Giants (5:05PM ET, Monday)

Our model has identified value on over 7.5 runs in Diamondbacks vs. Giants at +102 odds. A 55.8% probability produces an edge of 6.3%, making this the strongest play for today's MLB slate.

Astros vs. Rangers over 8.5 runs (+102)

• Edge: 5.7%
• Probability: 55.2%
• Matchup: Astros vs. Rangers (7:05PM ET, Monday)

Astros vs. Rangers over 8.5 runs carries a 5.7% edge and a probability of 55.2% at +102 odds, according to our model.

Cardinals vs. Brewers over 7.5 runs (-106)

• Edge: 4.7%
• Probability: 56.2%
• Matchup: Cardinals vs. Brewers (2:10PM ET, Monday)

Cardinals vs. Brewers over 7.5 runs at -106 odds shows a 4.7% edge, supported by a 56.2% probability in simulations.

Twins vs. White Sox over 8.5 runs (+115)

• Edge: 4.7%
• Probability: 51.2%
• Matchup: Twins vs. White Sox (2:10PM ET, Monday)

A 4.7% edge and 51.2% probability make Twins vs. White Sox over 8.5 runs at a value play in the Twins vs. White Sox matchup, per our model.

Phillies vs. Padres over 7.5 runs (+106)

• Edge: 4.6%
• Probability: 53.1%
• Matchup: Phillies vs. Padres (6:40PM ET, Monday)

Phillies vs. Padres over 7.5 runs at +106 odds presents a 4.6% edge, with simulations resulting in a probability of 53.1%.

Nationals vs. Guardians over 8.5 runs (+113)

• Edge: 4.4%
• Probability: 51.4%
• Matchup: Nationals vs. Guardians (6:10PM ET, Monday)

Our model finds value on over 8.5 runs in Nationals vs. Guardians at +113 odds, supported by an edge of 4.4%.

Marlins vs. Blue Jays over 7.5 runs (+102)

• Edge: 4.3%
• Probability: 53.8%
• Matchup: Marlins vs. Blue Jays (7:07PM ET, Monday)

Our model has uncovered value on Marlins vs. Blue Jays over 7.5 runs at +102 odds. A 53.8% probability produces a 4.3% edge, making this a strong play for today's MLB action.

Rays vs. Orioles over 7.5 runs (-106)

• Edge: 4.1%
• Probability: 55.6%
• Matchup: Rays vs. Orioles (1:35PM ET, Monday)

A 4.1% edge on a 55.6% probability makes over 7.5 runs at -106 odds a solid value play in today's Rays vs. Orioles matchup.

Orioles +1.5 (-127)

• Edge: 4.1%
• Probability: 60.1%
• Matchup: Rays vs. Orioles (1:35PM ET, Monday)

Our model projects value on Orioles +1.5 at -127 odds. A 60.1% probability produces a 4.1% edge, making Orioles the favorable side in Saturday’s matchup.

Reds vs. Mets over 7.5 runs (+102)

• Edge: 4.1%
• Probability: 53.6%
• Matchup: Reds vs. Mets (4:10PM ET, Monday)

Rounding out our top 10 bets, Reds vs. Mets over 7.5 runs at +102 odds shows a 53.6% probability and a 4.1% edge.

MLB best bets summary: Monday, 5/25/2026

As of 4:02AM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB games to bet on [5/25/2026]

• Cubs vs. Pirates (1:35PM ET, Monday)
• Rays vs. Orioles (1:35PM ET, Monday)
• Cardinals vs. Brewers (2:10PM ET, Monday)
• Twins vs. White Sox (2:10PM ET, Monday)
• Yankees vs. Royals (3:40PM ET, Monday)
• Reds vs. Mets (4:10PM ET, Monday)
• D-Backs vs. Giants (5:05PM ET, Monday)
• Nationals vs. Guardians (6:10PM ET, Monday)
• Phillies vs. Padres (6:40PM ET, Monday)
• Astros vs. Rangers (7:05PM ET, Monday)
• Marlins vs. Blue Jays (7:07PM ET, Monday)
• Rockies vs. Dodgers (9:10PM ET, Monday)
• Mariners vs. Athletics (9:40PM ET, Monday)

Conclusion

Our MLB best bets are locked and loaded for May 25, 2026, featuring plays such as over 7.5 runs in the Diamondbacks vs. Giants matchup and over 8.5 runs in the Astros vs. Rangers matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are based on current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.