Missouri State vs. Xavier prediction: Xavier favored to win men's college basketball matchup [12/12/2025]

Xavier and Missouri State will meet in men's college basketball action at Cintas Center on Friday, starting at 7:00PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model predicts Xavier as the most likely winner of the Missouri State vs. Xavier game.

This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Missouri State vs. Xavier prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the outcome of Friday's NCAA basketball matchup between Missouri State and Xavier 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Xavier a 94% chance of defeating Missouri State. Our predicted final score has Xavier winning 83-65.

According to our model, Xavier (-18.5) has a 52% chance of covering the spread, while the 148.5-point over/under has a 52% chance of staying under.

Missouri State vs. Xavier odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Missouri State vs. Xavier picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: