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Missouri State vs. Xavier prediction: Xavier favored to win men's college basketball matchup [12/12/2025]

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Written by Mac Douglass

Get Missouri State vs Xavier predictions for college basketball Friday.

Missouri State-Xavier Predictions and Game Preview.
Missouri State vs. Xavier men's college basketball prediction for Friday, December 12, 2025.

Xavier will face Missouri State in men's college basketball action at Cintas Center on Friday, commencing at 7:00PM ET.

Based on updated simulations, Dimers' proven college basketball model predicts Xavier as the most likely winner of the Missouri State vs. Xavier game.

This article offers an expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Missouri State vs. Xavier prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the result of Friday's NCAA basketball game between Missouri State and Xavier 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Xavier a 95% chance of beating Missouri State. Our predicted final score has Xavier winning 85-66.

According to our model, Xavier (-18.5) has a 52% chance of covering the spread, while the over/under total of 151.5 points has an equal 50-50 chance of hitting.

 

Missouri State vs. Xavier odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

Bet Type Missouri State Xavier
Spread +18.5 (-105) -18.5 (-108)
Moneyline +1400 -2100
Total o151.5 (-110) u151.5 (-105)

All odds are correct at the time of publication and are subject to change.

Missouri State vs. Xavier picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread Xavier -18.5 -108
Moneyline Xavier -2100
Total Under 151.5 -105

According to our best men's college basketball bets, the top play to make on this game is Xavier -18.5 at the spread.

 

Missouri State vs. Xavier game-day updates and essential details

Friday's men's college basketball game between Xavier and Missouri State at Cintas Center is scheduled to begin at 7:00PM ET.

  • Who: Missouri State vs. Xavier
  • Date: Friday, December 12, 2025
  • Time: 7:00PM ET/4:00PM PT
  • Venue: Cintas Center

Conclusion

We predict Xavier, with a 95% win probability, will likely beat Missouri State on Friday.

AI and automation have enhanced this article to quickly deliver accurate Missouri State vs. Xavier insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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