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Brewers vs. Cardinals prediction: Milwaukee favored to win Monday's MLB matchup [5/4/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Milwaukee Brewers vs St. Louis Cardinals predictions for MLB Monday.
The St. Louis Cardinals and Milwaukee Brewers will meet in MLB action at Busch Stadium on Monday, starting at 7:45 PM ET.
The Cardinals will have Kyle Leahy (3-3, 5.52 ERA) as their starting pitcher, while the Brewers will counter with Chad Patrick (2-1, 2.57 ERA).
Based on the latest simulations, Dimers' advanced MLB model gives the Brewers a slight edge with a 53% win probability over the Cardinals.
This article offers further insights into Monday's Brewers vs. Cardinals matchup, including best bets and picks.
Brewers vs. Cardinals prediction: Who will win and cover?
Using innovative machine learning and data analysis, we have simulated the outcome of Monday's MLB game between the Brewers and Cardinals, forming part of our MLB predictions coverage.
Our independent predictive model gives the Brewers a 53% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 59% chance of covering the run line, while the 9-run over/under has an equal 50-50 chance of hitting.
Brewers vs. Cardinals odds [5/4/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Brewers | Cardinals |
|---|---|---|
| Run Line | -1.5 (+133) | +1.5 (-146) |
| Moneyline | -126 | +110 |
| Total | o9 (-105) | u9 (-112) |
All odds are correct at the time of publication and are subject to change.
Brewers vs. Cardinals picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cardinals +1.5 | -146 |
| Moneyline | Cardinals | +110 |
| Total | Over 9 | -105 |
According to our MLB best bets, the top play to make on this game is Cardinals +1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Brewers vs. Cardinals game-day updates and essential details
Monday's MLB game between the Cardinals and Brewers at Busch Stadium is scheduled to start at 7:45 PM ET.
- Who: Milwaukee Brewers vs. St. Louis Cardinals
- Date: Monday, May 4, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict the Brewers, with a 53% win probability, will likely beat the Cardinals in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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