Michigan State vs. Penn State prediction: Why Michigan State is favored to win men's college basketball matchup [12/13/2025]

Men's college basketball action continues on Saturday at 12:00PM ET as the favored Michigan State takes on Penn State in men's college basketball action at Bryce Jordan Center.

Based on the latest simulations, Dimers' advanced college basketball model predicts Michigan State as the most likely winner of the Michigan State vs. Penn State game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Michigan State vs. Penn State prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the result of Saturday's NCAA basketball matchup between Michigan State and Penn State 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Michigan State an 82% chance of beating Penn State. Our predicted final score has Michigan State winning 77-68.

According to our model, Penn State (+12.5) has a 56% chance of covering the spread, while the 145.5-point over/under has a 52% chance of going over.

Michigan State vs. Penn State odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Michigan State vs. Penn State picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: