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Michigan State vs. Ohio State CFB Predictions and Odds - Nov 20, 2021

Ohio State faces Michigan State in College Football Week 12 action at Ohio Stadium on Saturday, starting at 12:00 PM EST.

Dimers' top betting picks for Michigan State vs. Ohio State, as well as our score prediction and best odds, are detailed below.


Who will win Michigan State vs. Ohio State?

Using cutting-edge computer power and data, Dimers.com has simulated Saturday's Michigan State-Ohio State NCAA Football matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives Ohio State an 83% chance of beating Michigan State.

MORE: Michigan State vs. Ohio State simulated 10,000 times

Michigan State vs. Ohio State Point Spread, Moneyline and Over/Under

Ohio State is the -20 favorite at home to Michigan State, with -105 at DraftKings Sportsbook the best odds available.

For the underdog Michigan State (+20) to cover the spread, DraftKings Sportsbook also has the best odds on offer at -115.

DraftKings Sportsbook has the best moneyline odds for Ohio State at -900. That means you can risk $900 to win $100, for a total payout of $1000, if it gets the W.

Elsewhere, FanDuel Sportsbook has the best moneyline odds for Michigan State at +710, where you can bet $100 to profit $710, earning a total payout of $810, if it wins.

The Over/Under sits at 69.5 with FanDuel Sportsbook, which has the best odds for the Over at -110, while DraftKings Sportsbook has the best odds for the Under at -105.

As always, make sure you check all the sportsbooks that are available in your state for the best College Football odds and lines.

According to DimersBOT, Michigan State (+20) is a 51% chance of covering the spread, while the 69.5-point Over/Under is considered an equal 50-50 chance of hitting.

MORE: Predictions for every College Football Week 12 matchup

Best Bets for Michigan State vs. Ohio State


Any time you see a πŸ”₯, that means it's one of Dimers' best free picks of the day across all sports.

Even though Michigan State is more likely to cover the spread, our best bet of Ohio State -20 is based on the chance of that happening, according to DimersBOT, and the top odds available.

And while Ohio State is more likely to win the game, according to DimersBOT, betting on Michigan State moneyline is the best option due to the 4.4% edge identified when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges seen here at Dimers.com is one of the keys to being profitable in the long run.

Michigan State vs. Ohio State Score Prediction

Dimers.com's predicted final score for Michigan State vs. Ohio State at Ohio Stadium this Saturday has Ohio State winning 44-25.


Dimers has full coverage of this week's Michigan State-Ohio State matchup, including pre-game predictions, top betting picks, and live scores.

Remember, DimersBOT updates frequently, so keep an eye on this article for any changes ahead of Michigan State vs. Ohio State on Saturday November 20, 2021.


Michigan State vs. Ohio State 2021 CFB Game Info

When does Ohio State play Michigan State in College Football?

  • Date: Saturday November 20, 2021
  • Time: 12:00 PM EST / 9:00 AM PST
  • Venue: Ohio Stadium

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Want more College Football previews like this?

So, you liked our Michigan State vs. Ohio State betting preview? Awesome. Did you know our College Football Betting News section has a comprehensive betting preview for every CFB game as soon as the sportsbooks put out their odds?

That's right, our predictive analytics model then compares those odds against its own probabilities to find value in the markets, which allows us to produce the most accurate CFB betting previews and beat the public and the sportsbooks to the punch.

It's only a click away, so why not take a look around?

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