Mercer vs. Clemson prediction: Why Clemson is favored to win men's college basketball matchup [12/13/2025]

Clemson will square off with Mercer in men's college basketball action at Littlejohn Coliseum on Saturday, starting at 3:00PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts Clemson as the most likely winner of the Mercer vs. Clemson game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Mercer vs. Clemson prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Saturday's NCAA basketball game between Mercer and Clemson 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Clemson a 97% chance of beating Mercer. Our predicted final score has Clemson winning 85-62.

According to our model, the bookmakers have got it right, and Mercer and Clemson each have a 50% chance of covering the spread, while the over/under total of 149.5 points also has an equal 50-50 chance of hitting.

Mercer vs. Clemson odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Mercer vs. Clemson picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: