Men's college basketball picks today: Sunday's best bets include Gonzaga vs. Oregon play [12/21/2025]

Oregon ML (+660)

• Edge: 9.4%
• Probability: 22.5%
• Matchup: Gonzaga vs. Oregon (6:00PM ET, Sunday)

Our model has identified value on Oregon to defeat Gonzaga at +660 odds. A 22.5% probability produces an edge of 9.4%, making this the strongest play for today's men's college basketball slate.

New Mexico State ML (-135)

• Edge: 7.3%
• Probability: 64.7%
• Matchup: Sam Houston State vs. New Mexico State (4:00PM ET, Sunday)

New Mexico State ML carries a 7.3% edge and a probability of 64.7% at -135 odds, according to our model.

Alabama A&M +2.5 (-102)

• Edge: 7.2%
• Probability: 57.7%
• Matchup: Chattanooga vs. Alabama A&M (3:00PM ET, Sunday)

Alabama A&M +2.5 vs. Chattanooga at -102 odds shows a 7.2% edge, supported by a 57.7% probability in simulations.

Gardner-Webb +40.5 (-104)

• Edge: 7.0%
• Probability: 58%
• Matchup: Gardner-Webb vs. Tennessee (3:00PM ET, Sunday)

A 7.0% edge and 58% probability make Gardner-Webb +40.5 vs. Tennessee at a value play in the Gardner-Webb vs. Tennessee matchup, per our model.

Albany +5.5 (-105)

• Edge: 6.8%
• Probability: 58%
• Matchup: Cornell vs. Albany (3:00PM ET, Sunday)

Albany +5.5 at -105 odds presents a 6.8% edge, with simulations resulting in a probability of 58%.

La Salle +39.5 (-110)

• Edge: 6.6%
• Probability: 59%
• Matchup: La Salle vs. Michigan (4:00PM ET, Sunday)

Our model finds value on La Salle +39.5 at -110 odds, supported by an edge of 6.6%.

Illinois-Chicago +2.5 (-105)

• Edge: 6.5%
• Probability: 57.7%
• Matchup: Illinois-Chicago vs. Charlotte (2:00PM ET, Sunday)

Our model has uncovered value on Illinois-Chicago +2.5 at -105 odds. A 57.7% probability produces a 6.5% edge, making this a strong play for today's men's college basketball action.

Oregon +12.5 (-110)

• Edge: 6.5%
• Probability: 58.9%
• Matchup: Gonzaga vs. Oregon (6:00PM ET, Sunday)

A 6.5% edge on a 58.9% probability makes Oregon +12.5 at -110 odds a solid value play in today's Gonzaga vs. Oregon matchup.

Bradley -6.5 (-105)

• Edge: 6.1%
• Probability: 57.3%
• Matchup: Southern Illinois vs. Bradley (2:00PM ET, Sunday)

Our model projects value on Bradley -6.5 at -105 odds. A 57.3% probability produces a 6.1% edge, making Bradley the favorable side in Saturday’s matchup.

Northern Kentucky -2.5 (-110)

• Edge: 6.0%
• Probability: 58.4%
• Matchup: Illinois-Chicago vs. Charlotte (12:00PM ET, Sunday)

Rounding out our top 10 bets, Northern Kentucky -2.5 at -110 odds shows a 58.4% probability and a 6.0% edge.

NCAAM best bets summary: Sunday, 12/21/2025

As of 4:31AM ET, here are our top men's college basketball bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Gonzaga vs. Oregon	Oregon ML	+660 @ FanDuel	9.4%	22.5%
Sam Houston State vs. New Mexico State	New Mexico State ML	-135 @ DraftKings	7.3%	64.7%
Chattanooga vs. Alabama A&M	Alabama A&M +2.5	-102 @ BetMGM	7.2%	57.7%
Gardner-Webb vs. Tennessee	Gardner-Webb +40.5	-104 @ FanDuel	7.0%	58%
Cornell vs. Albany	Albany +5.5	-105 @ DraftKings	6.8%	58%
La Salle vs. Michigan	La Salle +39.5	-110 @ BetMGM	6.6%	59%
Illinois-Chicago vs. Charlotte	Illinois-Chicago +2.5	-105 @ BetMGM	6.5%	57.7%
Gonzaga vs. Oregon	Oregon +12.5	-110 @ FanDuel	6.5%	58.9%
Southern Illinois vs. Bradley	Bradley -6.5	-105 @ BetMGM	6.1%	57.3%
Charleston vs. Northern Kentucky	Northern Kentucky -2.5	-110 @ FanDuel	6.0%	58.4%

List of upcoming men's college basketball games to bet on now

• Charleston vs. Northern Kentucky (12:00PM ET, Sunday)
• Penn State vs. Pittsburgh (12:00PM ET, Sunday)
• Colgate vs. Florida (12:00PM ET, Sunday)
• Massachusetts-Lowell vs. Boston University (12:00PM ET, Sunday)
• Ole Miss vs. North Carolina State (1:00PM ET, Sunday)
• Vanderbilt vs. Wake Forest (1:00PM ET, Sunday)
• Southern University vs. Baylor (1:00PM ET, Sunday)
• Quinnipiac vs. Hofstra (1:00PM ET, Sunday)
• Stony Brook vs. Marist (1:00PM ET, Sunday)
• Lehigh vs. Monmouth (1:00PM ET, Sunday)

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Conclusion

Our men's college basketball best bets are locked and loaded for December 21, 2025, featuring plays such as Oregon ML and New Mexico State ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college basketball insights quickly, with human oversight ensuring high editorial quality. Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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