Men's college basketball picks today: Monday's best bets include Northern Iowa vs. Saint Mary's play [12/22/2025]

Today’s men's college basketball picks for December 22, 2025 are here, with Northern Iowa vs. Saint Mary's among the top plays identified by our model across Monday’s men's college basketball slate.

Dimers’ predictive analytics engine runs 24/7, going over the latest men's college basketball odds to uncover top betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of NCAAM picks tonight [12/22, updated 9:31PM ET]

Below, you’ll find today’s best men's college basketball bets, ranked by edge for Monday, December 22, 2025.

Saint Mary's -11.5 (-108)

• Edge: 4.0%
• Probability: 55.9%
• Matchup: Northern Iowa vs. Saint Mary's (10:00PM ET, Monday)

Our model has identified value on Saint Mary's -11.5 at -108 odds. A 55.9% probability produces an edge of 4.0%, making this the strongest play for today's men's college basketball slate.

Northern Iowa vs. Saint Mary's over 131.5 points (-110)

• Edge: 2.3%
• Probability: 54.7%
• Matchup: Northern Iowa vs. Saint Mary's (10:00PM ET, Monday)

Northern Iowa vs. Saint Mary's over 131.5 points carries a 2.3% edge and a probability of 54.7% at -110 odds, according to our model.

Harvard vs. St. John's over 145.5 points (-105)

• Edge: 2.7%
• Probability: 53.9%
• Matchup: Harvard vs. St. John's (6:00PM ET, Tuesday)

A 2.7% edge and 53.9% probability make Harvard vs. St. John's over 145.5 points at a value play in the Harvard vs. St. John's matchup, per our model.

Northern Iowa vs. Saint Mary's over 131.5 points (-110)

• Edge: 2.3%
• Probability: 54.7%
• Matchup: Northern Iowa vs. Saint Mary's (10:00PM ET, Monday)

Northern Iowa vs. Saint Mary's over 131.5 points at -110 odds presents a 2.3% edge, with simulations resulting in a probability of 54.7%.

NCAAM best bets summary: Monday, 12/22/2025

As of 9:31PM ET, here are our top men's college basketball bets by edge recommended by our model:

List of upcoming men's college basketball games to bet on now

• San Diego vs. Washington (10:00PM ET, Monday)
• Northern Iowa vs. Saint Mary's (10:00PM ET, Monday)
• Sacramento State vs. Cal State Northridge (10:00PM ET, Monday)
• Green Bay vs. Campbell (12:00PM ET, Tuesday)
• Binghamton vs. Army (12:00PM ET, Tuesday)
• Bellarmine vs. Kentucky (1:00PM ET, Tuesday)
• Grambling State vs. Ohio State (2:00PM ET, Tuesday)
• Florida Atlantic vs. UCF (2:00PM ET, Tuesday)
• UC Riverside vs. UCLA (4:00PM ET, Tuesday)
• Idaho vs. Cal State Bakersfield (5:00PM ET, Tuesday)

What Is Dimebot?

Dimebot is Dimers’ AI bet assistant, designed to surface swift insights, answer betting questions, and help you explore data more efficiently.

Conclusion

Our men's college basketball best bets are locked and loaded for December 22, 2025, featuring plays such as Saint Mary's -11.5 and over 131.5 points also in the Northern Iowa vs. Saint Mary's matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college basketball insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

Note: Clicking links to our sportsbook partners may earn us a referral fee. Learn about how we review products and services.