Memphis vs. Mississippi State prediction: Why Mississippi State is favored to win men's college basketball matchup [12/20/2025]

Mississippi State will square off with Memphis in men's college basketball action at Humphrey Coliseum on Saturday, starting at 4:00 PM ET.

Based on updated simulations, Dimers' proven college basketball model predicts Mississippi State as the most likely winner of the Memphis vs. Mississippi State game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Memphis vs. Mississippi State prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Saturday's NCAA basketball matchup between Memphis and Mississippi State 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Mississippi State a 60% chance of beating Memphis. Our predicted final score has Mississippi State winning 77-74.

According to our model, Memphis (+3.5) has a 56% chance of covering the spread, while the over/under total of 152.5 points has an equal 50-50 chance of hitting.

Memphis vs. Mississippi State odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Memphis vs. Mississippi State picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: