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Memphis vs. Mississippi State prediction: Why Mississippi State is favored to win men's college basketball matchup [12/20/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Memphis vs Mississippi State predictions for college basketball Saturday.
Mississippi State will square off with Memphis in men's college basketball action at Humphrey Coliseum on Saturday, beginning at 4:00 PM ET.
Based on the latest simulations, Dimers' advanced college basketball model predicts Mississippi State as the most likely winner of the Memphis vs. Mississippi State game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Memphis vs. Mississippi State prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the result of Saturday's NCAA basketball matchup between Memphis and Mississippi State 10,000 times as part of our men's college basketball predictions coverage.
Our leading predictive model currently gives Mississippi State a 60% chance of defeating Memphis. Our predicted final score has Mississippi State winning 78-75.
According to our model, Memphis (+3.5) has a 56% chance of covering the spread, while the 152.5-point over/under has a 52% chance of staying under.
Memphis vs. Mississippi State odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Memphis | Mississippi State |
|---|---|---|
| Spread | +3.5 (-110) | -3.5 (-110) |
| Moneyline | +146 | -170 |
| Total | o152.5 (-115) | u152.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Memphis vs. Mississippi State picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Memphis +3.5 | -110 |
| Moneyline | Memphis | +146 |
| Total | Under 152.5 | -105 |
According to our best men's college basketball bets, the top play to make on this game is Memphis +3.5 at the spread.
Memphis vs. Mississippi State game-day updates and essential details
Saturday's men's college basketball action between Mississippi State and Memphis at Humphrey Coliseum is scheduled to begin at 4:00 PM ET.
- Who: Memphis vs. Mississippi State
- Date: Saturday, December 20, 2025
- Time: 4:00 PM ET/1:00PM PT
- Venue: Humphrey Coliseum
Conclusion
We predict Mississippi State, with a 60% win probability, will likely beat Memphis on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Memphis vs. Mississippi State insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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