Memphis vs. Louisville prediction: Louisville favored to win men's college basketball matchup [12/13/2025]

Louisville will take on Memphis in men's college basketball action at KFC Yum! Center on Saturday, beginning at 3:30PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts Louisville as the most likely winner of the Memphis vs. Louisville game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Memphis vs. Louisville prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Saturday's NCAA basketball game between Memphis and Louisville 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Louisville a 92% chance of defeating Memphis. Our predicted final score has Louisville winning 88-71.

According to our model, Louisville (-15.5) has a 54% chance of covering the spread, while the 160.5-point over/under has an equal 50-50 chance of hitting.

Memphis vs. Louisville odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Memphis vs. Louisville picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: