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Massachusetts-Lowell vs. Boston University prediction: Boston University favored to win men's college basketball matchup [12/21/2025]

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Written by Jason Bevilacqua

Get Massachusetts-Lowell vs Boston University predictions for college basketball Sunday.

Massachusetts-Lowell-Boston University Predictions and Game Preview.
Massachusetts-Lowell vs. Boston University men's college basketball prediction for Sunday, December 21, 2025.

Boston University will face Massachusetts-Lowell in men's college basketball action at Case Gym on Sunday, commencing at 12:00 PM ET.

Based on updated simulation results, Dimers' proven college basketball model projects Boston University as the most likely winner of the Massachusetts-Lowell vs. Boston University game.

This article offers a closer look at Sunday's matchup, including an expanded look at the predicted score, best bets and picks.

Massachusetts-Lowell vs. Boston University prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Sunday's NCAA basketball game between Massachusetts-Lowell and Boston University 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Boston University a 62% chance of beating Massachusetts-Lowell. Our predicted final score has Boston University winning 73-70.

According to our model, Massachusetts-Lowell (+5.5) has a 61% chance of covering the spread, while the over/under total of 145.5 points has a 53% chance of staying under.

 

Massachusetts-Lowell vs. Boston University odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

Bet Type Massachusetts-Lowell Boston University
Spread +5.5 (-112) -5.5 (-105)
Moneyline +205 -218
Total o145.5 (-110) u145.5 (-110)

All odds are correct at the time of publication and are subject to change.

Massachusetts-Lowell vs. Boston University picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread Massachusetts-Lowell +5.5 -112
Moneyline Massachusetts-Lowell +205
Total Under 145.5 -110

According to our best men's college basketball bets, the top play to make on this game is Massachusetts-Lowell +5.5 at the spread.

 

Massachusetts-Lowell vs. Boston University game-day updates and essential details

Sunday's men's college basketball action between Boston University and Massachusetts-Lowell at Case Gym is scheduled to begin at 12:00 PM ET.

  • Who: Massachusetts-Lowell vs. Boston University
  • Date: Sunday, December 21, 2025
  • Time: 12:00 PM ET/9:00AM PT
  • Venue: Case Gym

Conclusion

We predict Boston University, with a 62% win probability, will likely beat Massachusetts-Lowell on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Massachusetts-Lowell vs. Boston University insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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