Mariners vs. Astros Prediction and Odds - May 4, 2022

The Houston Astros and Seattle Mariners are scheduled to meet in MLB at Minute Maid Park on Wednesday, starting at 2:10PM ET.

Justin Verlander (2-1, 1.73 ERA) will be on the bump for the Astros, up against Matt Brash (1-2, 6.88 ERA) for the Mariners.

Dimers' top betting picks for Mariners vs. Astros, as well as game predictions and best odds, are featured in this article.

This Seattle vs. Houston betting analysis is presented by PointsBet, which has an outstanding 5x $100 Risk-Free Bets offer for new users.

Who will win Mariners vs. Astros?

Based on trusted machine learning and data, Dimers.com has simulated Wednesday's Mariners-Astros MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently gives the Astros a 65% chance of beating the Mariners.

More: Mariners vs. Astros Simulated 10,000 Times

Mariners vs. Astros Odds

• Run Line: Astros -1.5 (-106), Mariners +1.5 (-105)
• Moneyline: Astros -225, Mariners +195
• Total: Over/Under 7.5 (-118/+100)

Run Line, Moneyline and Over/Under

The Astros are currently -1.5 favorites versus the Mariners, with -106 at FanDuel Sportsbook the best odds currently available.

For the underdog Mariners (+1.5) to cover the run line, PointsBet has the best odds currently on offer at -105.

BetMGM currently has the best moneyline odds for the Astros at -225. That means you can risk $225 to win $100, for a total payout of $325, if they get the W.

Meanwhile, DraftKings Sportsbook currently has the best moneyline odds for the Mariners at +195, where you can bet $100 to profit $195, earning a total payout of $295, if they win.

The Over/Under for total runs scored is set at 7.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -118, while PointsBet currently has the best odds for the Under at +100.

As always, check out the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Mariners (+1.5) are a 54% chance of covering the run line, while the Over/Under total of 7.5 runs is a 53% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Mariners vs. Astros

• Run Line: Mariners +1.5 @ -105 via PointsBet (54% probability)
• Moneyline: Mariners @ +195 via DraftKings Sportsbook (1.4% edge)
• Total: Over 7.5 @ -118 via FanDuel Sportsbook (53% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to serve you the best possible plays every day of the year.

While the Astros are more likely to win the game, according to DimersBOT, betting on the Mariners moneyline is the best option because of the 1.4% edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen here at Dimers.com is pivotal to achieving long-term profitability as a bettor.

Mariners vs. Astros Probabilities

Use our interactive widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for Seattle vs. Houston, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Wednesday's Mariners-Astros matchup, including pregame predictions, free betting picks, and live win probabilities.

Remember, DimersBOT updates often, so check this page for the latest betting insights before Mariners vs. Astros on Wednesday May 4, 2022.

Best Betting Promo for Mariners vs. Astros

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Mariners vs. Astros 2022 Game Info

When do the Astros play the Mariners?

• Date: Wednesday May 4, 2022
• Time: 2:10PM ET / 11:10AM PT
• Venue: Minute Maid Park

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Want more MLB previews like this?

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That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find value in the markets, which allows us to produce the most authoritative MLB betting previews and beat the public and the sportsbooks to the punch.

It's only a click away, so why not take a look around?

While you're here, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds available.