Mackenzie McDonald vs. Karen Khachanov Prediction, Odds, Picks for ATP Libema Open 2025

Mackenzie McDonald will square off with Karen Khachanov in the round of 16 at the ATP S-Hertogenbosch event on Wednesday.

Based on the latest simulation results, Dimers' proven tennis model (see Dimers Pro for full access) projects Karen Khachanov as the most likely winner of the match.

"We have simulated the outcome of Wednesday's McDonald-Khachanov match 10,000 times," said Dimers data analyst Greg Butyn.

"With the latest updates and numerous other variables, we estimate Karen Khachanov's chance of winning at 63%, with Mackenzie McDonald at 37%."

For expanded analysis of Wednesday's match, including best bets and picks, visit our interactive McDonald vs. Khachanov predictions page.

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McDonald vs. Khachanov Prediction: Who Will Win and Advance to the Quarterfinals?

Using innovative machine learning and data, we have simulated the result of Wednesday's McDonald-Khachanov men's singles match 10,000 times as part of our tennis predictions coverage.

Our famous predictive model currently gives Khachanov a 63% chance of defeating McDonald at the ATP Libema Open tournament.

Additionally, Khachanov has a 59% chance of winning the first set, according to our model.

Pre-Match Probabilities

Last Updated: 8:04PM, Jun 11

Moneyline

1st Set

MackenzieMcDonald

Win %

36%

64%

+175

-227

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See Matchup

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KarenKhachanov

MackenzieMcDonald

+175

Win %

36%

64%

See Matchup

KarenKhachanov

-227

Get the best bets with Dimers Pro

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Mackenzie McDonald vs. Karen Khachanov Odds

We have sourced the most up-to-date betting odds in America for this match, which are listed here:

All odds are correct at the time of publication and are subject to change.

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McDonald vs. Khachanov Picks and Best Bets

Our model's strongest edge in today's McDonald vs. Khachanov match is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best tennis picks and tennis best bets for every match throughout the year.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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McDonald vs. Khachanov Updates and Essential Details

The ATP Libema Open match between Mackenzie McDonald and Karen Khachanov is scheduled to start on Wednesday at 9:05AM ET.

• Who: Mackenzie McDonald vs. Karen Khachanov
• Date: Wednesday, June 11, 2025
• Approx. Time: 9:05AM ET/6:05AM PT
• Tournament: ATP S-Hertogenbosch, Netherlands Men's Singles 2025
• Round: Round of 16

All dates and times mentioned in this article are United States Eastern Time unless otherwise stated.

Dimers.com's in-depth preview of Wednesday's McDonald vs. Khachanov match includes our prediction, picks and the latest betting odds.

Before making any Mackenzie McDonald vs. Karen Khachanov picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

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Conclusion

We predict Karen Khachanov, with a 63% win probability, will likely beat Mackenzie McDonald at the ATP Libema Open tournament.

AI and automation have enhanced this article to quickly deliver accurate McDonald vs. Khachanov insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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