Loyola (MD) vs. American University prediction: Why American University is favored to win men's college basketball matchup [12/31/2025]

American University will square off with Loyola (MD) in men's college basketball action at Bender Arena on Wednesday, commencing at 1:00 PM ET.

Based on updated simulation results, Dimers' proven college basketball model predicts American University as the most likely winner of the Loyola (MD) vs. American University game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Loyola (MD) vs. American University prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the result of Wednesday's NCAA basketball matchup between Loyola (MD) and American University 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives American University an 82% chance of beating Loyola (MD). Our predicted final score has American University winning 81-71.

According to our model, American University (-8.5) has a 57% chance of covering the spread, while the 153.5-point over/under has a 53% chance of staying under.

Loyola (MD) vs. American University odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Loyola (MD) vs. American University picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is American University -8.5 at the spread.

Loyola (MD) vs. American University game-day updates and essential details

Wednesday's men's college basketball action between American University and Loyola (MD) at Bender Arena is scheduled to begin at 1:00 PM ET.

• Who: Loyola (MD) vs. American University
• Date: Wednesday, December 31, 2025
• Time: 1:00 PM ET/10:00AM PT
• Venue: Bender Arena

Conclusion

We predict American University, with an 82% win probability, will likely beat Loyola (MD) on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Loyola (MD) vs. American University insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.