Loyola (MD) vs. American University prediction: Why American University is favored to win men's college basketball matchup [12/31/2025]

American University will face Loyola (MD) in men's college basketball action at Bender Arena on Wednesday, starting at 1:00 PM ET.

Based on updated simulation results, Dimers' proven college basketball model projects American University as the most likely winner of the Loyola (MD) vs. American University game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Loyola (MD) vs. American University prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball game between Loyola (MD) and American University 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives American University an 81% chance of beating Loyola (MD). Our predicted final score has American University winning 82-72.

According to our model, American University (-8.5) has a 57% chance of covering the spread, while the 156.5-point over/under has a 52% chance of staying under.

Loyola (MD) vs. American University odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Loyola (MD) vs. American University picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: