Loyola Chicago vs. Santa Clara prediction: Santa Clara favored to win men's college basketball matchup [12/20/2025]

Santa Clara will take on Loyola Chicago in men's college basketball action at Kaiser Permanente Arena on Saturday, starting at 5:00 PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts Santa Clara as the most likely winner of the Loyola Chicago vs. Santa Clara game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Loyola Chicago vs. Santa Clara prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Saturday's NCAA basketball game between Loyola Chicago and Santa Clara 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Santa Clara a 95% chance of beating Loyola Chicago. Our predicted final score has Santa Clara winning 85-65.

According to our model, Santa Clara (-17.5) has a 55% chance of covering the spread, while the 150.5-point over/under has an equal 50-50 chance of hitting.

Loyola Chicago vs. Santa Clara odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Loyola Chicago vs. Santa Clara picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: