Louisville vs. Indiana prediction: Why Louisville is favored to win men's college basketball matchup [12/6/2025]

Indiana will square off with Louisville in men's college basketball action at Gainbridge Fieldhouse on Saturday, commencing at 2:15PM ET.

Based on updated simulations, Dimers' proven college basketball model predicts Louisville as the most likely winner of the Louisville vs. Indiana game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Louisville vs. Indiana prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Saturday's NCAA basketball matchup between Louisville and Indiana 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Louisville a 63% chance of beating Indiana. Our predicted final score has Louisville winning 80-77.

According to our model, Indiana (+4.5) has a 55% chance of covering the spread, while the 161.5-point over/under has a 54% chance of staying under.

Louisville vs. Indiana odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Louisville vs. Indiana picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: